Long non-coding rnas as functional codes for oral cancer: Translational potential, progress and promises

研究成果: 雜誌貢獻回顧型文獻同行評審

摘要

Oral cancer is one of the leading malignant tumors worldwide. Despite the advent of mul-tidisciplinary approaches, the overall prognosis of patients with oral cancer is poor, mainly due to late diagnosis. There is an urgent need to develop valid biomarkers for early detection and effective therapies. Long non-coding RNAs (lncRNAs) are recognized as key elements of gene regulation, with pivotal roles in various physiological and pathological processes, including cancer. Over the past few years, an exponentially growing number of lncRNAs have been identified and linked to tumorigenesis and prognosis outcomes in oral cancer, illustrating their emerging roles in oral cancer progression and the associated signaling pathways. Herein, we aim to summarize the most recent advances made concerning oral cancer-associated lncRNA, and their expression, involvement, and potential clinical impact, reported to date, with a specific focus on the lncRNA-mediated molecular regulation in oncogenic signaling cascades and oral malignant progression, while exploring their potential, and challenges, for clinical applications as biomarkers or therapeutic targets for oral can-cer.

原文英語
文章編號4903
期刊International journal of molecular sciences
22
發行號9
DOIs
出版狀態已發佈 - 五月 1 2021

ASJC Scopus subject areas

  • 催化
  • 分子生物學
  • 光譜
  • 電腦科學應用
  • 物理與理論化學
  • 有機化學
  • 無機化學

指紋

深入研究「Long non-coding rnas as functional codes for oral cancer: Translational potential, progress and promises」主題。共同形成了獨特的指紋。

引用此