Local mobility of nucleic acids as determined from crystallographic data. II. Z-form DNA

Stephen R. Holbrook, Andrew H.J. Wang, Alexander Rich, Sung Hou Kim

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

Directions and magnitudes of the local mobility of the Z-DNA hexamer duplex CpGpCpGpCpG have been determined by crystallographic refinement of anisotropic displacement parameters using the observed X-ray diffraction data. The cytidine and guanosine residues demonstrate different modes of mobility, implying that a dinucleotide is the smallest repeating unit in terms of flexibility as well as structure. Directions of librational and translational mobility of the cytidine and guanosine residues of Z-DNA are similar to those observed for the same nucleotides in B-DNA. This suggests that the local mobility of DNA is primarily determined by the individual nucleotide type and by the constraints of Watson-Crick base-pairing, rather than by helical form. Differences in the magnitudes of mobility may be responsible for some of the different physical properties of B-DNA and Z-DNA. The B to Z transition is discussed in terms of the observed flexibilities of these two helical forms.

原文英語
頁(從 - 到)429-440
頁數12
期刊Journal of Molecular Biology
187
發行號3
DOIs
出版狀態已發佈 - 2月 5 1986
對外發佈

ASJC Scopus subject areas

  • 結構生物學
  • 分子生物學

指紋

深入研究「Local mobility of nucleic acids as determined from crystallographic data. II. Z-form DNA」主題。共同形成了獨特的指紋。

引用此