Liver-directed regional therapy in the multi-disciplinary management of hepatocellular cancer

Maheswari Senthil, Brian Mailey, Lucille Leong, Vincent Chung, Yun Yen, Yi Jen Chen, Howard Marx, Joseph Kim

研究成果: 雜誌貢獻文章

6 引文 (Scopus)

摘要

Hepatocellular carcinoma (HCC) is a major worldwide health concern with an increasing incidence in the United States. Orthotopic liver transplantation (OLT) has been established as the gold standard for curative therapy of HCC. Because of limited organ supply and socioeconomic factors, OLT is often not a viable option. Surgical resection and ablation are also effective for providing long-term survival. However, most patients are ineligible for curative surgical therapy due to advanced disease. For these patients, effective treatment options have been lacking. Systemic chemotherapy and even recent biologic, targeted agents have shown little to minimal efficacy. Liver-directed regional therapies, including trans-arterial chemoembolization (TACE) and selective internal radiation treatment (SIRT) with Yttrium-90 radioembolization have emerged in recent years as effective therapies to provide local control of disease. Randomized trials have demonstrated a survival benefit for TACE, and SIRT has shown efficacy as an embolic alternative to TACE. Here we review the experience of liver-directed regional therapies and provide a clear rationale for their implementation in a multi-disciplinary algorithmic approach to the management of HCC.
原文英語
頁(從 - 到)19-25
頁數7
期刊Current Cancer Therapy Reviews
6
發行號1
DOIs
出版狀態已發佈 - 二月 2010
對外發佈Yes

指紋

Liver Neoplasms
Liver
Hepatocellular Carcinoma
Therapeutics
Liver Transplantation
Radiation
Yttrium
Survival
Biological Factors
Drug Therapy
Incidence

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Molecular Medicine

引用此文

Liver-directed regional therapy in the multi-disciplinary management of hepatocellular cancer. / Senthil, Maheswari; Mailey, Brian; Leong, Lucille; Chung, Vincent; Yen, Yun; Chen, Yi Jen; Marx, Howard; Kim, Joseph.

於: Current Cancer Therapy Reviews, 卷 6, 編號 1, 02.2010, p. 19-25.

研究成果: 雜誌貢獻文章

Senthil, Maheswari ; Mailey, Brian ; Leong, Lucille ; Chung, Vincent ; Yen, Yun ; Chen, Yi Jen ; Marx, Howard ; Kim, Joseph. / Liver-directed regional therapy in the multi-disciplinary management of hepatocellular cancer. 於: Current Cancer Therapy Reviews. 2010 ; 卷 6, 編號 1. 頁 19-25.
@article{46fa7c8bec1140de94cb2e7c6d530b79,
title = "Liver-directed regional therapy in the multi-disciplinary management of hepatocellular cancer",
abstract = "Hepatocellular carcinoma (HCC) is a major worldwide health concern with an increasing incidence in the United States. Orthotopic liver transplantation (OLT) has been established as the gold standard for curative therapy of HCC. Because of limited organ supply and socioeconomic factors, OLT is often not a viable option. Surgical resection and ablation are also effective for providing long-term survival. However, most patients are ineligible for curative surgical therapy due to advanced disease. For these patients, effective treatment options have been lacking. Systemic chemotherapy and even recent biologic, targeted agents have shown little to minimal efficacy. Liver-directed regional therapies, including trans-arterial chemoembolization (TACE) and selective internal radiation treatment (SIRT) with Yttrium-90 radioembolization have emerged in recent years as effective therapies to provide local control of disease. Randomized trials have demonstrated a survival benefit for TACE, and SIRT has shown efficacy as an embolic alternative to TACE. Here we review the experience of liver-directed regional therapies and provide a clear rationale for their implementation in a multi-disciplinary algorithmic approach to the management of HCC.",
keywords = "Chemoembolization, Hepatocellular cancer, Liver-directed therapy, Radioembolization, Regional therapy",
author = "Maheswari Senthil and Brian Mailey and Lucille Leong and Vincent Chung and Yun Yen and Chen, {Yi Jen} and Howard Marx and Joseph Kim",
year = "2010",
month = "2",
doi = "10.2174/157339410790596461",
language = "English",
volume = "6",
pages = "19--25",
journal = "Current Cancer Therapy Reviews",
issn = "1573-3947",
publisher = "Bentham Science Publishers B.V.",
number = "1",

}

TY - JOUR

T1 - Liver-directed regional therapy in the multi-disciplinary management of hepatocellular cancer

AU - Senthil, Maheswari

AU - Mailey, Brian

AU - Leong, Lucille

AU - Chung, Vincent

AU - Yen, Yun

AU - Chen, Yi Jen

AU - Marx, Howard

AU - Kim, Joseph

PY - 2010/2

Y1 - 2010/2

N2 - Hepatocellular carcinoma (HCC) is a major worldwide health concern with an increasing incidence in the United States. Orthotopic liver transplantation (OLT) has been established as the gold standard for curative therapy of HCC. Because of limited organ supply and socioeconomic factors, OLT is often not a viable option. Surgical resection and ablation are also effective for providing long-term survival. However, most patients are ineligible for curative surgical therapy due to advanced disease. For these patients, effective treatment options have been lacking. Systemic chemotherapy and even recent biologic, targeted agents have shown little to minimal efficacy. Liver-directed regional therapies, including trans-arterial chemoembolization (TACE) and selective internal radiation treatment (SIRT) with Yttrium-90 radioembolization have emerged in recent years as effective therapies to provide local control of disease. Randomized trials have demonstrated a survival benefit for TACE, and SIRT has shown efficacy as an embolic alternative to TACE. Here we review the experience of liver-directed regional therapies and provide a clear rationale for their implementation in a multi-disciplinary algorithmic approach to the management of HCC.

AB - Hepatocellular carcinoma (HCC) is a major worldwide health concern with an increasing incidence in the United States. Orthotopic liver transplantation (OLT) has been established as the gold standard for curative therapy of HCC. Because of limited organ supply and socioeconomic factors, OLT is often not a viable option. Surgical resection and ablation are also effective for providing long-term survival. However, most patients are ineligible for curative surgical therapy due to advanced disease. For these patients, effective treatment options have been lacking. Systemic chemotherapy and even recent biologic, targeted agents have shown little to minimal efficacy. Liver-directed regional therapies, including trans-arterial chemoembolization (TACE) and selective internal radiation treatment (SIRT) with Yttrium-90 radioembolization have emerged in recent years as effective therapies to provide local control of disease. Randomized trials have demonstrated a survival benefit for TACE, and SIRT has shown efficacy as an embolic alternative to TACE. Here we review the experience of liver-directed regional therapies and provide a clear rationale for their implementation in a multi-disciplinary algorithmic approach to the management of HCC.

KW - Chemoembolization

KW - Hepatocellular cancer

KW - Liver-directed therapy

KW - Radioembolization

KW - Regional therapy

UR - http://www.scopus.com/inward/record.url?scp=77949891779&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949891779&partnerID=8YFLogxK

U2 - 10.2174/157339410790596461

DO - 10.2174/157339410790596461

M3 - Article

AN - SCOPUS:77949891779

VL - 6

SP - 19

EP - 25

JO - Current Cancer Therapy Reviews

JF - Current Cancer Therapy Reviews

SN - 1573-3947

IS - 1

ER -