Liquid chromatographic assay of phenothiazine, thioxanthene and butyrophenone neuroleptics and antihistamines in blood and plasma with conventional and radial compression columns and UV and electrochemical detection

Stephen H. Curry, Edgar A. Brown, Oliver Y.P. Hu, John H. Perrin

研究成果: 雜誌貢獻文章

45 引文 (Scopus)

摘要

An assay strategy for determining a wide range of phenothiazine, thioxanthene and butyrophenone neuroleptics and antihistamines both alone and in combination in blood and plasma is described. The general method employs liquid chromatography with both conventional and radial compression nitrile bonded columns. Detection is by ultraviolet absorption spectrophotometry or by amperometry depending on the concentrations to be measured. Ultraviolet absorption is suitable down to 10 ng/ml. Below this level amperometry is preferable. The various compounds are used as internal standards for each other. The lower limit of detection is approximately 0.1 ng ml-1 with a 10-ml sample. The within-run coefficient of variation is a maximum of 7.3%.
原文英語
頁(從 - 到)361-376
頁數16
期刊Journal of Chromatography B: Biomedical Sciences and Applications
231
發行號2
DOIs
出版狀態已發佈 - 九月 10 1982
對外發佈Yes

指紋

Thioxanthenes
Butyrophenones
Nitriles
Histamine Antagonists
Liquid chromatography
Spectrophotometry
Antipsychotic Agents
Assays
Blood
Plasmas
Liquids
phenothiazine

ASJC Scopus subject areas

  • Chemistry(all)

引用此文

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abstract = "An assay strategy for determining a wide range of phenothiazine, thioxanthene and butyrophenone neuroleptics and antihistamines both alone and in combination in blood and plasma is described. The general method employs liquid chromatography with both conventional and radial compression nitrile bonded columns. Detection is by ultraviolet absorption spectrophotometry or by amperometry depending on the concentrations to be measured. Ultraviolet absorption is suitable down to 10 ng/ml. Below this level amperometry is preferable. The various compounds are used as internal standards for each other. The lower limit of detection is approximately 0.1 ng ml-1 with a 10-ml sample. The within-run coefficient of variation is a maximum of 7.3{\%}.",
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