Liposomes incorporated with cholesterol for drug release triggered by magnetic field

Li Ping Tseng, Hong Jen Liang, Tze Wen Chung, Yi You Huang, Der Zen Liu

研究成果: 雜誌貢獻文章

49 引文 斯高帕斯(Scopus)

摘要

Liposome formulated with cholesterol at different ratios was used to investigate the extent of drug release triggered by magnetic forces. Liposomes were prepared at various ratios of DPPC/cholesterol (4:0, 4:0.5, 4:1, 4:2, at 5 mM lipid concentration), and encapsulated 5(6)-Carboxylfluorescein [5(6)-CF] by the method of thin film hydration. They were then characterized by differential scanning calorimetry (DSC) and deformability experiments to investigate the relationship between physical stability and the addition of cholesterol. The influence of magnetic field on the release of encapsulated drug was also investigated. The results showed that deformability of liposomes decreased in terms of an increase in liposomal stability with increasing cholesterol incorporation. The zeta potential and particle sizes for liposomes under different strengths magnetic field changed dramatically, suggesting that the magnetic orientation of the lipid molecules caused changes in zeta potential and particle size. Liposome of DPPC/cholesterol=4:1 exhibited the highest physical stability and showed a 66% difference in drug release over the absence of a magnetic field. Liposome of DPPC/cholesterol=4:1 seems to be the optimal liposome formulation for drug release under a magnetic field.

原文英語
頁(從 - 到)29-34
頁數6
期刊Journal of Medical and Biological Engineering
27
發行號1
出版狀態已發佈 - 三月 2007

    指紋

ASJC Scopus subject areas

  • Biophysics
  • Medicine (miscellaneous)
  • Biotechnology

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