Liposomes incorporated with cholesterol for drug release triggered by magnetic field

Li Ping Tseng, Hong Jen Liang, Tze Wen Chung, Yi You Huang, Der Zen Liu

研究成果: 雜誌貢獻文章

47 引文 (Scopus)

摘要

Liposome formulated with cholesterol at different ratios was used to investigate the extent of drug release triggered by magnetic forces. Liposomes were prepared at various ratios of DPPC/cholesterol (4:0, 4:0.5, 4:1, 4:2, at 5 mM lipid concentration), and encapsulated 5(6)-Carboxylfluorescein [5(6)-CF] by the method of thin film hydration. They were then characterized by differential scanning calorimetry (DSC) and deformability experiments to investigate the relationship between physical stability and the addition of cholesterol. The influence of magnetic field on the release of encapsulated drug was also investigated. The results showed that deformability of liposomes decreased in terms of an increase in liposomal stability with increasing cholesterol incorporation. The zeta potential and particle sizes for liposomes under different strengths magnetic field changed dramatically, suggesting that the magnetic orientation of the lipid molecules caused changes in zeta potential and particle size. Liposome of DPPC/cholesterol=4:1 exhibited the highest physical stability and showed a 66% difference in drug release over the absence of a magnetic field. Liposome of DPPC/cholesterol=4:1 seems to be the optimal liposome formulation for drug release under a magnetic field.

原文英語
頁(從 - 到)29-34
頁數6
期刊Journal of Medical and Biological Engineering
27
發行號1
出版狀態已發佈 - 三月 2007

指紋

Liposomes
Cholesterol
Magnetic Fields
Magnetic fields
Zeta potential
Formability
Particle Size
Lipids
Particle size
Differential Scanning Calorimetry
Drug Liberation
Hydration
Differential scanning calorimetry
Thin films
Molecules

ASJC Scopus subject areas

  • Biophysics
  • Medicine (miscellaneous)
  • Biotechnology

引用此文

Liposomes incorporated with cholesterol for drug release triggered by magnetic field. / Tseng, Li Ping; Liang, Hong Jen; Chung, Tze Wen; Huang, Yi You; Liu, Der Zen.

於: Journal of Medical and Biological Engineering, 卷 27, 編號 1, 03.2007, p. 29-34.

研究成果: 雜誌貢獻文章

Tseng, Li Ping ; Liang, Hong Jen ; Chung, Tze Wen ; Huang, Yi You ; Liu, Der Zen. / Liposomes incorporated with cholesterol for drug release triggered by magnetic field. 於: Journal of Medical and Biological Engineering. 2007 ; 卷 27, 編號 1. 頁 29-34.
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