Lipid profiles in children with and without asthma: Interaction of asthma and obesity on hyperlipidemia

Yang Ching Chen, Kuan Yen Tung, Ching Hui Tsai, Ming Wei Su, Pei Chuan Wang, Chien Han Chen, Yungling Leo Lee

研究成果: 雜誌貢獻文章

23 引文 斯高帕斯(Scopus)

摘要

Aims: The joint effect of obesity and asthma on hyperlipidemia has never been explored. We aim to examine (1) the association of dyslipidemia and asthma, (2) the interaction effect of asthma and obesity on hyperlipidemia, and (3) whether a gender difference existed in the above relationships. Methods: Between 2009 and 2010, 10- to 15-year-old children were recruited from 7 schools and 2 hospitals in Northern Taiwan. The population consisted of 237 asthmatic children and 225 non-asthmatic controls, and was further divided into four groups: non-obese controls, obese controls, non-obese asthmatics, and obese asthmatics. Measurements included anthropometric measures and blood samples for analysis of metabolic factors. The Cook's criteria were used to define childhood metabolic syndrome. General linear models were used to analyze how lipid profiles were associated with obesity and asthma. Results: Total cholesterol and low density lipoprotein cholesterol levels increased progressively in the group order obese asthmatics > non-obese asthmatics > obese controls > non-obese controls. In boys, low density lipoprotein cholesterol levels were significantly higher in obese asthmatics compared to obese non-asthmatics, with a mean difference of 6.2 mmol/L in the general linear model. We also discovered a significant interactive effect of obesity and asthma on hyperlipidemia in boys (p for interaction = 0.03). Conclusions: Asthma was associated with higher low density lipoprotein cholesterol levels and this association was amplified in overweight and obese subjects. A gender difference was observed in the joint effect of obesity and asthma on hyperlipidemia.

原文英語
頁(從 - 到)20-25
頁數6
期刊Diabetes and Metabolic Syndrome: Clinical Research and Reviews
7
發行號1
DOIs
出版狀態已發佈 - 一月 1 2013
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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