OBJECTIVE: We investigated lipid metabolism in hypercholesterolemic rats after replacing casein with different amounts of undialyzed soybean protein fraction. METHODS: The hypercholesterolemic rats were fed cholesterol-free diets containing 2%, 5%, or 10% undialyzed soybean protein fraction (UDSP) for 4 wk. RESULTS: The 5% and 10% UDSP groups had significantly lower plasma cholesterol, triacylglycerol, and low-density lipoprotein cholesterol concentrations than did the other groups (P < 0.05). In addition, significantly higher fecal total steroid excretion was observed in these two groups. However, the different amounts of UDSP did not influence liver lipid, plasma high-density lipoprotein cholesterol, body weight gain, daily food intake, or feeding efficiency. CONCLUSION: These results suggested a dose-dependent reduction in plasma cholesterol when casein was replaced stepwise with UDSP (5% or 10%) as a protein source. The hypocholesterolemic effect might have been due to an increase in total fecal steroid excretion.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Medicine (miscellaneous)
Chen, J. R., Chiou, S. F., Suetsuna, K., Yang, H. Y., & Yang, S. C. (2003). Lipid metabolism in hypercholesterolemic rats affected by feeding cholesterol-free diets containing different amounts of non-dialyzed soybean protein fraction. Nutrition, 19(7-8), 676-680. https://doi.org/10.1016/S0899-9007(03)00072-8