Lignans and tannins as inhibitors of viral reverse transcriptase and human DNA polymerase-α: Qsar analysis and molecular modeling

Karin C S Chen Liu, Shoei Sheng Lee, Mei Tsu Lin, Chia Wen Chang, Chao Lin Liu, Jung Yaw Lin, Feng Lin Hsu, Shijun Ren, Eric J. Lien

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

The inhibitory activities against HIV-1 RT and hDNAP-α of 15 lignans and tannins isolated from Chinese herbs have been correlated with physicochemical parameters (μ, log MW, Hb, I). From the overall shapes of 3-D structures, a T-shaped perpendicular ring system gives the best differential inhibition against HIV-1 RT, while a more complicated π-shaped ring system is associated with high inhibition against both HIV-1 RT and hDNAP-α. These findings indicate that there are different structural requirements for the inhibition of each of the target enzyme.
原文英語
頁(從 - 到)168-179
頁數12
期刊Medicinal Chemistry Research
7
發行號3
出版狀態已發佈 - 1997

ASJC Scopus subject areas

  • 有機化學
  • 藥物發現

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