Background: Little research focuses on the influence of lifetime residential mobility on health at midlife. We used a national survey of participant recall of residential mobility to assess this issue and explore the mediating and moderating effects of personal and environmental context. Methods: In March 2010, we collected data from people in Taiwan aged 40 to 60 years. Based on the household registration system, data were collected using the population proportional-to-size sampling method and a computerassisted telephone interview. A total of 2834 participants completed the interview. Based on the 3490 registered households, the overall response rate was 81.2%. Results: The mean cumulative frequency of geographic relocation (CFGR) was 3.06 ± 2.78 times and ranged from 0 to 21. After carefully adjusting for the heterogeneity of demographic and socioeconomic propensity, total CFGR was significantly positively associated with negative self-rated mental (odds ratio [OR] and 95% CI for increase per time: 1.06, 1.02-1.16) and physical (OR and 95% CI for increase per time: 1.16, 1.05-1.26) health. Social network support lessened the impact of total CFGR on self-rated mental health. In addition to the primary effect, the interaction (residential environmental satisfaction × total CFGR) significantly moderated negative mental health and negative physical health. Conclusions: Lifetime residential mobility history independently influenced midlife health. Social network support and satisfaction with the residential environment in past and current living places further mediated or moderated midlife health. Findings from these different perspectives offer insights for future medical care projects and epidemiologic studies.
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