Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest

Wan Jung Lu, Gong Jhe Wu, Ray Jade Chen, Chao Chien Chang, Li Ming Lien, Ching Chuan Chiu, Mei Fang Tseng, Li Ting Huang, Kuan Hung Lin

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

摘要

Licochalcone A (LA), an active ingredient of licorice, has multiple biological activities, including antioxidative and anti-inflammatory activities. Although LA exerts antitumor effects in various cancer cells, its role in gliomas remains unclear. Therefore, this study determined whether LA inhibits glioma cell growth in vitro and in vivo. The present data revealed that LA effectively inhibited the growth of U87 glioma cells by inducing cell cycle arrest in the G0/G1 and G2/M phases; cell cycle arrest was attributed to the LA-mediated reduction of mRNA and protein levels of cyclins and cyclin-dependent kinases. Moreover, subcutaneous (flank) and orthotopic (brain) tumor models were used to determine the role of LA in gliomas. LA significantly alleviated tumor growth in both models. These findings indicate that LA exerts antitumor effects in gliomas in vitro and in vivo and that it is a potential agent for treating glioblastoma multiforme.
原文英語
頁(從 - 到)4500-4507
頁數8
期刊Food and Function
9
發行號8
DOIs
出版狀態已發佈 - 八月 1 2018

ASJC Scopus subject areas

  • Food Science

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