Levels of plasma selenium and urinary total arsenic interact to affect the risk for prostate cancer

Yu Mei Hsueh, Chien Tien Su, Horng Sheng Shiue, Wei Jen Chen, Yeong Shiau Pu, Ying Chin Lin, Cheng Shiuan Tsai, Chao Yuan Huang

研究成果: 雜誌貢獻文章

7 引文 (Scopus)

摘要

This study investigated whether plasma selenium levels modified the risk for prostate cancer (PC) related to arsenic exposure. We conducted a case-control study that included 318 PC patients and 318 age-matched, healthy control subjects. Urinary arsenic profiles were examined using HPLC-HG-AAS and plasma selenium levels were measured by ICP-MS. We found that plasma selenium levels displayed a significant dose-dependent inverse association with PC. The odds ratio (OR) and 95% confidence interval (CI) for PC was 0.07 (0.04–0.13) among participants with a plasma selenium level >28.06 μg/dL vs. ≤19.13 μg/dL. A multivariate analysis showed that participants with a urinary total arsenic concentration >29.28 μg/L had a significantly higher OR (1.75, 1.06–2.89) for PC than participants with ≤29.89 μg/L. The combined presence of a low plasma selenium level and a high urinary total arsenic concentration exponentially increased the OR for PC, and additively interacted with PSA at levels ≥20 ng/mL. This is the first epidemiological study to examine the combined effects of plasma selenium and urinary total arsenic levels on the OR for PC. Our data suggest a low plasma selenium level coupled with a high urinary total arsenic concentration creates a significant risk for aggressive PC.
原文英語
頁(從 - 到)167-175
頁數9
期刊Food and Chemical Toxicology
107
DOIs
出版狀態已發佈 - 九月 1 2017

指紋

Arsenic
prostatic neoplasms
Selenium
arsenic
selenium
Prostatic Neoplasms
Plasmas
odds ratio
Odds Ratio
Inductively coupled plasma
case-control studies
epidemiological studies
multivariate analysis
Case-Control Studies
Epidemiologic Studies
confidence interval
Healthy Volunteers
Multivariate Analysis
High Pressure Liquid Chromatography
Confidence Intervals

ASJC Scopus subject areas

  • Food Science
  • Toxicology

引用此文

Levels of plasma selenium and urinary total arsenic interact to affect the risk for prostate cancer. / Hsueh, Yu Mei; Su, Chien Tien; Shiue, Horng Sheng; Chen, Wei Jen; Pu, Yeong Shiau; Lin, Ying Chin; Tsai, Cheng Shiuan; Huang, Chao Yuan.

於: Food and Chemical Toxicology, 卷 107, 01.09.2017, p. 167-175.

研究成果: 雜誌貢獻文章

Hsueh, Yu Mei ; Su, Chien Tien ; Shiue, Horng Sheng ; Chen, Wei Jen ; Pu, Yeong Shiau ; Lin, Ying Chin ; Tsai, Cheng Shiuan ; Huang, Chao Yuan. / Levels of plasma selenium and urinary total arsenic interact to affect the risk for prostate cancer. 於: Food and Chemical Toxicology. 2017 ; 卷 107. 頁 167-175.
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