Leigh disease (subacute necrotizing encephalomyelopathy): report of one case.

T. S. Wu, C. C. Lee, J. T. Lin, H. H. Hsu, S. T. Lin, Y. J. Jong, E. Y. Shen

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)


A case is reported of a 16-month-old girl who presented with generalized hypotonia, ptosis and persistent low grade fever after a previous pneumonia. Brain CT and MRI showed symmetric necrotizing lesions in the basal ganglia, substantia nigra and periaqueduct area. Lactate and pyruvate levels were elevated in both the blood and cerebrospinal fluid. Biopsy of the rectus femoris muscle for electron microscopic examination revealed some distortion of the mitochondrial cristae. Biochemical study showed normal respiratory chain enzymes. Leigh disease was considered from the neuroradiological findings and morphological investigations.
頁(從 - 到)301-307
期刊Acta Paediatrica Sinica
出版狀態已發佈 - 7月 1993

ASJC Scopus subject areas

  • 兒科、圍產兒和兒童健康


深入研究「Leigh disease (subacute necrotizing encephalomyelopathy): report of one case.」主題。共同形成了獨特的指紋。