Left-handed double helical DNA: Variations in the backbone conformation

Andrew H.J. Wang, Gary J. Quigley, Francis J. Kolpak, Gijs Van Der Marel, Jacques H. Van Boom, Alexander Rich

研究成果: 雜誌貢獻文章同行評審

478 引文 斯高帕斯(Scopus)

摘要

Four different crystals of d(CpGpCpGpCpG) have been solved by x-ray diffraction analysis and all form similar left-handed double helical Z-DNA molecules in the crystal lattice. Two different conformations are observed for the phosphates in the GpC sequences, as the phosphates are found either facing the helical groove or rotated away from it. The latter conformation is often found when hydrated magnesium ions are complexed to a phosphate oxygen atom. These different conformations may be used when right-handed B-DNA joins left-handed Z-DNA. Atomic coordinates and torsion angles are presented for both types of Z-DNA.

原文英語
頁(從 - 到)171-176
頁數6
期刊Science
211
發行號4478
DOIs
出版狀態已發佈 - 1981
對外發佈

ASJC Scopus subject areas

  • 多學科

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