Latent TB infection in newly diagnosed lung cancer patients - A multicenter prospective observational study

Wen Chien Fan, Wen Ying Ting, Ming Che Lee, Shiang Fen Huang, Chao Hua Chiu, Shinn Liang Lai, Yuh Min Chen, Jen Fu Shih, Ching Hsiung Lin, Shang Jyh Kao, Ming Fang Wu, Thomas Chang Yao Tsao, Chieh Hung Wu, Kuang Yao Yang, Yu Chin Lee, Jia Yih Feng, Wei Juin Su

研究成果: 雜誌貢獻文章

8 引文 (Scopus)

摘要

Objectives: Lung cancer and tuberculosis (TB) share common risk factors and are associated with high morbidity and mortality. Coexistence of lung cancer and TB were reported in previous studies, with uncertain pathogenesis. The association between lung cancer and latent TB infection (LTBI) remains to be explored. Methods: Newly diagnosed, treatment-naïve lung cancer patients were prospectively enrolled from four referral medical centers in Taiwan. The presence of LTBI was determined by QuantiFERON-TB Gold In-Tube (QFT-GIT). Demographic characteristics and cancer-related factors associated with LTBI were investigated. The survival status was also analyzed according to the status of LTBI. Results: A total of 340 lung cancer patients were enrolled, including 96 (28.2%) LTBI, 214 (62.9%) non-LTBI, and 30 (8.8%) QFT-GIT results-indeterminate cases. Non-adenocarcinoma cases had higher proportion of LTBI than those of adenocarcinoma, especially in patients with younger age. In multivariate analysis, COPD (OR 2.41, 95% CI 1.25-4.64), fibrocalcified lesions on chest radiogram (OR 2.73, 95% CI 1.45-5.11), and main tumor located in typical TB areas (OR 2.02, 95% CI 1.15-3.55) were independent clinical predictors for LTBI. Kaplan-Meier survival analysis demonstrated patients with indeterminate QFT-GIT results had significantly higher 1-year all-cause mortality than those with LTBI (p<0.001) and non-LTBI (p = 0.003). In multivariate analysis, independent predictors for 1-year all-cause mortality included BMI. <18.5 (HR 2.09, 95% CI 1.06-4.14, p = 0.033), advanced stage of lung cancer (RR 7.76, 95% CI 1.90-31.78, p = 0.004), and indeterminate QFT-GIT results (RR 2.40, 95% CI 1.27-4.54, p = 0.007). Conclusions: More than one-quarter of newly diagnosed lung cancer patients in Taiwan have LTBI. The independent predictors for LTBI include COPD, fibrocalcified lesions on chest radiogram, and main tumor located in typical TB areas. The survival rate is comparable between LTBI and non-LTBI cases. However, indeterminate QFT-GIT result was an independent predictor for all-cause mortality in lung cancer patients.
原文英語
頁(從 - 到)472-478
頁數7
期刊Lung Cancer
85
發行號3
DOIs
出版狀態已發佈 - 2014

指紋

Latent Tuberculosis
Observational Studies
Lung Neoplasms
Prospective Studies
Infection
Gold
Tuberculosis
Mortality
Taiwan
Chronic Obstructive Pulmonary Disease
Thorax
Multivariate Analysis
Kaplan-Meier Estimate
Survival Analysis

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research
  • Medicine(all)

引用此文

Fan, W. C., Ting, W. Y., Lee, M. C., Huang, S. F., Chiu, C. H., Lai, S. L., ... Su, W. J. (2014). Latent TB infection in newly diagnosed lung cancer patients - A multicenter prospective observational study. Lung Cancer, 85(3), 472-478. https://doi.org/10.1016/j.lungcan.2014.07.001

Latent TB infection in newly diagnosed lung cancer patients - A multicenter prospective observational study. / Fan, Wen Chien; Ting, Wen Ying; Lee, Ming Che; Huang, Shiang Fen; Chiu, Chao Hua; Lai, Shinn Liang; Chen, Yuh Min; Shih, Jen Fu; Lin, Ching Hsiung; Kao, Shang Jyh; Wu, Ming Fang; Tsao, Thomas Chang Yao; Wu, Chieh Hung; Yang, Kuang Yao; Lee, Yu Chin; Feng, Jia Yih; Su, Wei Juin.

於: Lung Cancer, 卷 85, 編號 3, 2014, p. 472-478.

研究成果: 雜誌貢獻文章

Fan, WC, Ting, WY, Lee, MC, Huang, SF, Chiu, CH, Lai, SL, Chen, YM, Shih, JF, Lin, CH, Kao, SJ, Wu, MF, Tsao, TCY, Wu, CH, Yang, KY, Lee, YC, Feng, JY & Su, WJ 2014, 'Latent TB infection in newly diagnosed lung cancer patients - A multicenter prospective observational study', Lung Cancer, 卷 85, 編號 3, 頁 472-478. https://doi.org/10.1016/j.lungcan.2014.07.001
Fan, Wen Chien ; Ting, Wen Ying ; Lee, Ming Che ; Huang, Shiang Fen ; Chiu, Chao Hua ; Lai, Shinn Liang ; Chen, Yuh Min ; Shih, Jen Fu ; Lin, Ching Hsiung ; Kao, Shang Jyh ; Wu, Ming Fang ; Tsao, Thomas Chang Yao ; Wu, Chieh Hung ; Yang, Kuang Yao ; Lee, Yu Chin ; Feng, Jia Yih ; Su, Wei Juin. / Latent TB infection in newly diagnosed lung cancer patients - A multicenter prospective observational study. 於: Lung Cancer. 2014 ; 卷 85, 編號 3. 頁 472-478.
@article{02892ca1930a453aa286c6b0fa988b59,
title = "Latent TB infection in newly diagnosed lung cancer patients - A multicenter prospective observational study",
abstract = "Objectives: Lung cancer and tuberculosis (TB) share common risk factors and are associated with high morbidity and mortality. Coexistence of lung cancer and TB were reported in previous studies, with uncertain pathogenesis. The association between lung cancer and latent TB infection (LTBI) remains to be explored. Methods: Newly diagnosed, treatment-na{\"i}ve lung cancer patients were prospectively enrolled from four referral medical centers in Taiwan. The presence of LTBI was determined by QuantiFERON-TB Gold In-Tube (QFT-GIT). Demographic characteristics and cancer-related factors associated with LTBI were investigated. The survival status was also analyzed according to the status of LTBI. Results: A total of 340 lung cancer patients were enrolled, including 96 (28.2{\%}) LTBI, 214 (62.9{\%}) non-LTBI, and 30 (8.8{\%}) QFT-GIT results-indeterminate cases. Non-adenocarcinoma cases had higher proportion of LTBI than those of adenocarcinoma, especially in patients with younger age. In multivariate analysis, COPD (OR 2.41, 95{\%} CI 1.25-4.64), fibrocalcified lesions on chest radiogram (OR 2.73, 95{\%} CI 1.45-5.11), and main tumor located in typical TB areas (OR 2.02, 95{\%} CI 1.15-3.55) were independent clinical predictors for LTBI. Kaplan-Meier survival analysis demonstrated patients with indeterminate QFT-GIT results had significantly higher 1-year all-cause mortality than those with LTBI (p<0.001) and non-LTBI (p = 0.003). In multivariate analysis, independent predictors for 1-year all-cause mortality included BMI. <18.5 (HR 2.09, 95{\%} CI 1.06-4.14, p = 0.033), advanced stage of lung cancer (RR 7.76, 95{\%} CI 1.90-31.78, p = 0.004), and indeterminate QFT-GIT results (RR 2.40, 95{\%} CI 1.27-4.54, p = 0.007). Conclusions: More than one-quarter of newly diagnosed lung cancer patients in Taiwan have LTBI. The independent predictors for LTBI include COPD, fibrocalcified lesions on chest radiogram, and main tumor located in typical TB areas. The survival rate is comparable between LTBI and non-LTBI cases. However, indeterminate QFT-GIT result was an independent predictor for all-cause mortality in lung cancer patients.",
keywords = "Adenocarcinoma, COPD, Latent TB infection, Lung cancer, Mortality, Tuberculosis",
author = "Fan, {Wen Chien} and Ting, {Wen Ying} and Lee, {Ming Che} and Huang, {Shiang Fen} and Chiu, {Chao Hua} and Lai, {Shinn Liang} and Chen, {Yuh Min} and Shih, {Jen Fu} and Lin, {Ching Hsiung} and Kao, {Shang Jyh} and Wu, {Ming Fang} and Tsao, {Thomas Chang Yao} and Wu, {Chieh Hung} and Yang, {Kuang Yao} and Lee, {Yu Chin} and Feng, {Jia Yih} and Su, {Wei Juin}",
year = "2014",
doi = "10.1016/j.lungcan.2014.07.001",
language = "English",
volume = "85",
pages = "472--478",
journal = "Lung Cancer",
issn = "0169-5002",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Latent TB infection in newly diagnosed lung cancer patients - A multicenter prospective observational study

AU - Fan, Wen Chien

AU - Ting, Wen Ying

AU - Lee, Ming Che

AU - Huang, Shiang Fen

AU - Chiu, Chao Hua

AU - Lai, Shinn Liang

AU - Chen, Yuh Min

AU - Shih, Jen Fu

AU - Lin, Ching Hsiung

AU - Kao, Shang Jyh

AU - Wu, Ming Fang

AU - Tsao, Thomas Chang Yao

AU - Wu, Chieh Hung

AU - Yang, Kuang Yao

AU - Lee, Yu Chin

AU - Feng, Jia Yih

AU - Su, Wei Juin

PY - 2014

Y1 - 2014

N2 - Objectives: Lung cancer and tuberculosis (TB) share common risk factors and are associated with high morbidity and mortality. Coexistence of lung cancer and TB were reported in previous studies, with uncertain pathogenesis. The association between lung cancer and latent TB infection (LTBI) remains to be explored. Methods: Newly diagnosed, treatment-naïve lung cancer patients were prospectively enrolled from four referral medical centers in Taiwan. The presence of LTBI was determined by QuantiFERON-TB Gold In-Tube (QFT-GIT). Demographic characteristics and cancer-related factors associated with LTBI were investigated. The survival status was also analyzed according to the status of LTBI. Results: A total of 340 lung cancer patients were enrolled, including 96 (28.2%) LTBI, 214 (62.9%) non-LTBI, and 30 (8.8%) QFT-GIT results-indeterminate cases. Non-adenocarcinoma cases had higher proportion of LTBI than those of adenocarcinoma, especially in patients with younger age. In multivariate analysis, COPD (OR 2.41, 95% CI 1.25-4.64), fibrocalcified lesions on chest radiogram (OR 2.73, 95% CI 1.45-5.11), and main tumor located in typical TB areas (OR 2.02, 95% CI 1.15-3.55) were independent clinical predictors for LTBI. Kaplan-Meier survival analysis demonstrated patients with indeterminate QFT-GIT results had significantly higher 1-year all-cause mortality than those with LTBI (p<0.001) and non-LTBI (p = 0.003). In multivariate analysis, independent predictors for 1-year all-cause mortality included BMI. <18.5 (HR 2.09, 95% CI 1.06-4.14, p = 0.033), advanced stage of lung cancer (RR 7.76, 95% CI 1.90-31.78, p = 0.004), and indeterminate QFT-GIT results (RR 2.40, 95% CI 1.27-4.54, p = 0.007). Conclusions: More than one-quarter of newly diagnosed lung cancer patients in Taiwan have LTBI. The independent predictors for LTBI include COPD, fibrocalcified lesions on chest radiogram, and main tumor located in typical TB areas. The survival rate is comparable between LTBI and non-LTBI cases. However, indeterminate QFT-GIT result was an independent predictor for all-cause mortality in lung cancer patients.

AB - Objectives: Lung cancer and tuberculosis (TB) share common risk factors and are associated with high morbidity and mortality. Coexistence of lung cancer and TB were reported in previous studies, with uncertain pathogenesis. The association between lung cancer and latent TB infection (LTBI) remains to be explored. Methods: Newly diagnosed, treatment-naïve lung cancer patients were prospectively enrolled from four referral medical centers in Taiwan. The presence of LTBI was determined by QuantiFERON-TB Gold In-Tube (QFT-GIT). Demographic characteristics and cancer-related factors associated with LTBI were investigated. The survival status was also analyzed according to the status of LTBI. Results: A total of 340 lung cancer patients were enrolled, including 96 (28.2%) LTBI, 214 (62.9%) non-LTBI, and 30 (8.8%) QFT-GIT results-indeterminate cases. Non-adenocarcinoma cases had higher proportion of LTBI than those of adenocarcinoma, especially in patients with younger age. In multivariate analysis, COPD (OR 2.41, 95% CI 1.25-4.64), fibrocalcified lesions on chest radiogram (OR 2.73, 95% CI 1.45-5.11), and main tumor located in typical TB areas (OR 2.02, 95% CI 1.15-3.55) were independent clinical predictors for LTBI. Kaplan-Meier survival analysis demonstrated patients with indeterminate QFT-GIT results had significantly higher 1-year all-cause mortality than those with LTBI (p<0.001) and non-LTBI (p = 0.003). In multivariate analysis, independent predictors for 1-year all-cause mortality included BMI. <18.5 (HR 2.09, 95% CI 1.06-4.14, p = 0.033), advanced stage of lung cancer (RR 7.76, 95% CI 1.90-31.78, p = 0.004), and indeterminate QFT-GIT results (RR 2.40, 95% CI 1.27-4.54, p = 0.007). Conclusions: More than one-quarter of newly diagnosed lung cancer patients in Taiwan have LTBI. The independent predictors for LTBI include COPD, fibrocalcified lesions on chest radiogram, and main tumor located in typical TB areas. The survival rate is comparable between LTBI and non-LTBI cases. However, indeterminate QFT-GIT result was an independent predictor for all-cause mortality in lung cancer patients.

KW - Adenocarcinoma

KW - COPD

KW - Latent TB infection

KW - Lung cancer

KW - Mortality

KW - Tuberculosis

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JO - Lung Cancer

JF - Lung Cancer

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