Laser-induced withdrawal test for electrophysiological recordings of nociception

Yu-Chieh Jill Kao, Fu-Shan Jaw

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)


CO 2 lasers are often used in pain research. However, the stimulation parameters of the CO 2 lasers, such as beam diameter, laser power, etc., used for these animal nociceptive studies vary across laboratories. The differences of the parameters usually make novices who want to reproduce the laser-evoked responses confused to follow. In this study, we quantitatively measured the laser-withdrawal reflex of the rat to ascertain the individual laser-withdrawal threshold and then found the thresholds were diverse among the rats we adopted. Furthermore, the optimal stimulation distance, the most conveniently modified stimulation parameter of CO 2 laser stimuli, was also determined. We suggest that laser-withdrawal tests should be applied before the electrophysiological recordings in order to verify the efficiency of the induced nociception and substantiate the operational parameters of the CO 2 laser device. © 2011 Springer-Verlag.
頁(從 - 到)79-83
期刊Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology
出版狀態已發佈 - 2012


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