CO 2 lasers are often used in pain research. However, the stimulation parameters of the CO 2 lasers, such as beam diameter, laser power, etc., used for these animal nociceptive studies vary across laboratories. The differences of the parameters usually make novices who want to reproduce the laser-evoked responses confused to follow. In this study, we quantitatively measured the laser-withdrawal reflex of the rat to ascertain the individual laser-withdrawal threshold and then found the thresholds were diverse among the rats we adopted. Furthermore, the optimal stimulation distance, the most conveniently modified stimulation parameter of CO 2 laser stimuli, was also determined. We suggest that laser-withdrawal tests should be applied before the electrophysiological recordings in order to verify the efficiency of the induced nociception and substantiate the operational parameters of the CO 2 laser device. © 2011 Springer-Verlag.
|頁（從 - 到）||79-83|
|期刊||Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology|
|出版狀態||已發佈 - 2012|