Langerhans cells in 60 odontogenic keratocysts

Chun Han Chang, Yang Che Wu, Yu Hsueh Wu, Andy Sun, Hsin Ming Chen, Hung Pin Lin

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

摘要

Background/purpose Langerhans cells (LCs) are antigen-presenting cells. This study mainly evaluated the LC counts in 60 odontogenic keratocysts (OKCs). Materials and methods The CD1a-positive LC numbers in the lining epithelia and subepithelial connective tissues were counted at 60 OKC sites without inflammation, 39 OKC sites with mild/moderate inflammation, and 13 OKC sites with severe inflammation from 60 OKC specimens. Results The mean CD1a-positive LC counts in the lining epithelia and subepithelial connective tissues increased significantly from no inflammation (0.5 ± 0.4 and 0.2 ± 0.3 cell/high-power field or HPF, respectively) through mild/moderate inflammation (5.3 ± 2.5 and 2.5 ± 2.7 cells/HPF, respectively) to severe inflammation OKC sites (12.7 ± 5.6 and 9.3 ± 7.2 cells/HPF, respectively; all P-values < 0.001). OKC sites with inflammation had thicker lining epithelia than those without inflammation. Moreover, the mean CD1a-positive LC counts in the lining epithelia and subepithelial connective tissues of OKCs were significantly higher in the thicker lining epithelium (>100 μm) group (6.8 ± 5.1 and 3.7 ± 4.9 cells/HPF, respectively) than in the thinner lining epithelium (≦100 μm) group (1.0 ± 1.7 and 0.8 ± 2.5 cell/HPF, respectively; both P-values < 0.001). Conclusion There is a significant association of inflammation grade with the number of LCs in OKCs. The scarce LCs in the lining epithelia of OKCs without inflammation suggests the loss of immunosurveillance ability against the OKC lining epithelial cells; this can explain why OKCs have aggressive clinical behavior, a great growth potential, and a high recurrence rate.
原文英語
頁(從 - 到)283-290
頁數8
期刊Journal of Dental Sciences
12
發行號3
DOIs
出版狀態已發佈 - 九月 1 2017
對外發佈Yes

ASJC Scopus subject areas

  • Dentistry(all)

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    Chang, C. H., Wu, Y. C., Wu, Y. H., Sun, A., Chen, H. M., & Lin, H. P. (2017). Langerhans cells in 60 odontogenic keratocysts. Journal of Dental Sciences, 12(3), 283-290. https://doi.org/10.1016/j.jds.2017.04.001