Lactoferrin protects against chemical-induced rat liver fibrosis by inhibiting stellate cell activation

Yu Tang Tung, Ting Yu Tang, Hsiao Ling Chen, Shang Hsun Yang, Kowit Yu Chong, Winston T K Cheng, Chuan Mu Chen

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)

摘要

Liver diseases, which can be caused by alcohol abuse, chemical intoxication, viral hepatitis infection, and autoimmune disorders, are a significant health issue because they can develop into liver fibrosis and cirrhosis. Lactoferrin (LF), a siderophilic protein with 2 iron-binding sites, has been demonstrated to possess a multitude of biological functions, including antiinflammation, anticancer, and antimicrobial effects, as well as immunomodulatory-enhancing functions. In the current study, we induced hepatotoxicity in rats with dimethylnitrosamine (DMN) to establish a situation that would enable us to evaluate the hepatoprotective effects of LF against hepatic injury. Our results showed that DMN-induced hepatic pathological damage significantly decreased the body weight and liver index, increased the mRNA and protein levels of collagen α-1(I) (ColIα-1) and α-smooth muscle actin, and increased the hydroxyproline content. However, treatment with LF significantly increased body weight and liver index, decreased the mRNA and protein levels of ColIα-1 and α-smooth muscle actin, and suppressed the hydroxyproline content when compared with the DMN-treated group. Liver histopathology also showed that low-dose LF (100. mg/kg of body weight) or high-dose LF (300. mg/kg of body weight) could significantly reduce the incidences of liver lesions induced by DMN. These results suggest that the LF exhibits potent hepatoprotection against DMN-induced liver damage in rats and that the hepatoprotective effects of LF may be due to the inhibition of collagen production and to stellate cell activation.
原文英語
頁(從 - 到)3281-3291
頁數11
期刊Journal of Dairy Science
97
發行號6
DOIs
出版狀態已發佈 - 2014
對外發佈Yes

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology
  • Genetics

指紋 深入研究「Lactoferrin protects against chemical-induced rat liver fibrosis by inhibiting stellate cell activation」主題。共同形成了獨特的指紋。

  • 引用此