Lack of salivary long non‐coding rna xist expression is associated with increased risk of oral squamous cell carcinoma: A cross‐sectional study

Tzong Ming Shieh, Chung Ji Liu, Shih Min Hsia, Valendriyani Ningrum, Chiu Chu Liao, Wan Chen Lan, Yin Hwa Shih

研究成果: 雜誌貢獻文章同行評審

摘要

Studies have shown that there is a disparity between males and females in south‐east Asia with regard to oral cancer morbidity. A previous study found that oral cancer tissue showed loss of heterozygosity of the X‐linked lncRNA XIST gene. We suggest that XIST may play an important role in oral cancer morbidity when associated with sex. Saliva contains proteins and RNAs that are potential biomarkers for the diagnosis of diseases. This study investigated salivary XIST expression and the correlation to clinical–pathological data among oral squamous cell carcinoma patients. Salivary XIST expression was only observed in females, and a high proportion of females with OSCC lack salivary lncRNA XIST expression (88%). The expression showed no correlation with alcohol consumption, betel quid chewing, or cigarette smoking habits. People lacking salivary lncRNA XIST expression had a significantly increased odds ratio of suffering from OSCC (OR = 19.556, p < 0.001), particularly females (OR = 33.733, p < 0.001). The ROC curve showed that salivary lncRNA XIST expression has acceptable discrimination accuracy to predict the risk of OSCC (AUC = 0.73, p < 0.01). Lack of salivary lncRNA XIST expression was associated with an increased risk of OSCC. We pro-vided an insight into the role of salivary lncRNA XIST as a biomarker to predict the morbidity of OSCC.
原文英語
文章編號4622
期刊Journal of Clinical Medicine
10
發行號19
DOIs
出版狀態已發佈 - 10月 2021

ASJC Scopus subject areas

  • 醫藥 (全部)

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