L-ascorbic acid and alpha-tocopherol attenuates liver ischemia-reperfusion induced of cardiac function impairment

C. C. Hsu, J. J. Wang

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14 引文 斯高帕斯(Scopus)

摘要

Objectives: The Pringle maneuver is a surgical procedure to minimize hemorrhage during hepatectomy, which however, can induce production of reactive oxygen species causing remote organ injury. We sought to study the impact of the Pringle maneuver on cardiac function as well as the protective effects of L-ascorbic acid and α-tocopherol pretreatments. Methods: Rats were divided into four study groups: L-ascorbic acid (60 mg/kg/d) or α-tocopherol (200 mg/kg/d), and surgical interventions (Sham-operated or liver ischemia-reperfusion [I/R]). Liver ischemia was performed by clamping the hepatic artery and portal vein for 30 minutes, followed by reperfusion by releasing the clamps for 2 hours. Cardiac function was evaluated by a high-fidelity pressure-volume catheter positioned in the left ventricle. Myocardial injury was assessed through plasma creatine kinase-MB (CKMB) and troponin I (cTnI). Cardiac lipid peroxidation and systemic hydroxyl radical levels were assessed by cardiac tissue malondialdehyde and plasma methylguanidine, respectively. Results: Cardiac function was significantly depressed in the I/R group, where plasma CKMB and cTnI were markedly increased (P

原文英語
頁(從 - 到)933-936
頁數4
期刊Transplantation Proceedings
44
發行號4
DOIs
出版狀態已發佈 - 5月 2012
對外發佈

ASJC Scopus subject areas

  • 手術
  • 移植

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