Kinetic epidemiological model for elucidating sexual difference of hypertension (KCIS no.20)

Amy M F Yen, Tony H H Chen

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

Background Woman have lower rate of hypertension than man but it is still elusive how such gender difference can be explained by kinetic epidemiological curves. Objective The aim of this paper was to develop a multi-state model for delineating the kinetic epidemiology of hypertension according to the Seventh Report of the Joint National Committee (JNC 7) classification criteria by gender, and to derive gender-specific kinetic curves. Methods We used data from a population-based screening programme with 42 027 participants to fit a four-state Markov model corresponding to the classification of hypertension from the JNC 7. Results The young man had higher progression rate but lower regression rate for the movement between normal and pre-hypertension than the young woman. Such gender difference disappeared after 50 years old. The mean sojourn time of pre- and stage 1 hypertension for man and stage 1 for woman was approximately 5 years. However, the corresponding figure for pre-hypertension for woman was 25 years at age 30, 10 years at age 40 and 5 years afterwards. Conclusion Elucidating the kinetic epidemiological curves of hypertension explains higher prevalence rate in young man than woman. These findings fit with the role of sex hormones regulating blood pressure demonstrated in the animal model.
原文英語
頁(從 - 到)130-135
頁數6
期刊Journal of Evaluation in Clinical Practice
17
發行號1
DOIs
出版狀態已發佈 - 二月 2011
對外發佈Yes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health Policy

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