Jet nebulisation: Influence of dynamic conditions and nebuliser on nebulisation duality. Application to the α1 protease inhibitor

M. P. Flament, P. Leterme, T. Burnouf, A. T. Gayot

研究成果: 雜誌貢獻文章

8 引文 (Scopus)

摘要

The use of nebulisers lacks standardisation, which may account for certain inefficiency. As part of a study of α 1 protease inhibitor (α1 PI) nebulisation for pulmonary administration, we studied the influence of technological parameters that is to say the nebuliser and the dynamic conditions (airflow and pressure) on nebulisation quality. The quality of nebulisation is evaluated by measurement of the percentage of droplets below 5.79 μm, the quantity of α1 PI nebulised, the quantity of α1 PI likely to reach the lungs and nebulisation time. The use of different dynamic conditions results in variable nebulisation quality. Depending upon the power of the compressor and the type of nebuliser, drug delivery varies. The association of high airflow and high pressure improves the respirable fraction and compliance by decreasing nebulisation time. Although droplet size is a commonly used parameter, it is not sufficient to forecast efficiency. It must be associated with the quantity of drug nebulised and, to a lesser extent, nebulisation time. The nebuliser is also to be taken into consideration. The characteristics of the constituent nebuliser elements, that is to say liquid and air tube orifices, size and shape of the reservoir, shape and position of the impartion system, are preponderant on nebulisation quality.
原文英語
頁(從 - 到)93-101
頁數9
期刊International Journal of Pharmaceutics
148
發行號1
DOIs
出版狀態已發佈 - 三月 14 1997
對外發佈Yes

指紋

Nebulizers and Vaporizers
Protease Inhibitors
Pressure
Lung
Pharmaceutical Preparations
Compliance
Air

ASJC Scopus subject areas

  • Pharmaceutical Science

引用此文

Jet nebulisation : Influence of dynamic conditions and nebuliser on nebulisation duality. Application to the α1 protease inhibitor. / Flament, M. P.; Leterme, P.; Burnouf, T.; Gayot, A. T.

於: International Journal of Pharmaceutics, 卷 148, 編號 1, 14.03.1997, p. 93-101.

研究成果: 雜誌貢獻文章

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