Isotretinoin treatment for acne and risk of depression: A systematic review and meta-analysis

Yu-Chen Huang, Ying Chih Cheng

研究成果: 雜誌貢獻文章同行評審

78 引文 斯高帕斯(Scopus)

摘要

Background The relationship between isotretinoin treatment for acne and depression is controversial. Quantitative analysis has not yet been conducted. Objective To conduct a meta-analysis, evidence-based examination of the relationship between isotretinoin and depression. Method A systematic review and meta-analysis of the literature published from inception to September 30, 2016, was conducted. Controlled or prospective non-controlled trials on ≥15 acne patients receiving isotretinoin treatment were included. The prevalence of depression and change in depression scores were calculated. Result Thirty-one studies met the inclusion criteria. In the controlled studies, the change in depression scores from baseline was not significantly different between patients receiving isotretinoin treatment and those receiving an alternative treatment (standardized mean difference [SMD] −0.334, 95% confidence interval [CI] −0.680 to 0.011). The prevalence of depression after isotretinoin treatment significantly declined (relative risk [RR] 0.588, 95% CI 0.382–0.904). The mean depression scores significantly decreased from baseline (SMD −0.335, 95% CI −0.498 to −0.172). Limitations No randomized controlled trials were reviewed; a large inter-study variation was observed. Conclusions Isotretinoin treatment for acne does not appear to be associated with an increased risk for depression. Moreover, the treatment of acne appears to ameliorate depressive symptoms.

原文英語
頁(從 - 到)1068-1076.e9
期刊Journal of the American Academy of Dermatology
76
發行號6
DOIs
出版狀態已發佈 - 6月 1 2017

ASJC Scopus subject areas

  • 皮膚科

指紋

深入研究「Isotretinoin treatment for acne and risk of depression: A systematic review and meta-analysis」主題。共同形成了獨特的指紋。

引用此