Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Mei Chuan Chen, Guei Jane Wang, Yueh Hsiung Kuo, Yin Ru Chiang, Ting Yu Cho, Yu Ming Ju, Tzong Huei Lee

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with E max values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production.
原文英語
頁(從 - 到)111-117
頁數7
期刊Journal of Food and Drug Analysis
27
發行號1
DOIs
出版狀態已發佈 - 一月 1 2019

指紋

Xylaria
Isoptera
termite mounds
Ethers
nitric oxide
ethers
Nitric Oxide
Fungi
phenylephrine
mice
Phenylephrine
chest
Inbred C57BL Mouse
lipopolysaccharides
Lipopolysaccharides
cytotoxicity
data analysis
macrophages
Thorax
Macrophages

ASJC Scopus subject areas

  • Food Science
  • Pharmacology

引用此文

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata. / Chen, Mei Chuan; Wang, Guei Jane; Kuo, Yueh Hsiung; Chiang, Yin Ru; Cho, Ting Yu; Ju, Yu Ming; Lee, Tzong Huei.

於: Journal of Food and Drug Analysis, 卷 27, 編號 1, 01.01.2019, p. 111-117.

研究成果: 雜誌貢獻文章

Chen, Mei Chuan ; Wang, Guei Jane ; Kuo, Yueh Hsiung ; Chiang, Yin Ru ; Cho, Ting Yu ; Ju, Yu Ming ; Lee, Tzong Huei. / Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata. 於: Journal of Food and Drug Analysis. 2019 ; 卷 27, 編號 1. 頁 111-117.
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abstract = "Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with E max values ranging from 4.6 ± 2.0{\%} to 49.7 ± 0.5{\%} without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production.",
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AU - Chiang, Yin Ru

AU - Cho, Ting Yu

AU - Ju, Yu Ming

AU - Lee, Tzong Huei

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AB - Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with E max values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production.

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