Isopentenyladenosine stimulates and inhibits mitosis of human lymphocytes treated with phytohemagglutinin

Robert C. Gallo, Jacqueline Whang-Peng, Seymour Perry

研究成果: 雜誌貢獻文章

63 引文 斯高帕斯(Scopus)

摘要

The plant cytokinin isopentenyladenosine, a component of yeast and mammalian transfer ribonucleic acid, is both a potent inhibitor and stimulator of DNA synthesis, transformation, and mitosis of the phytohemagglutinin- stimulated lymphocyte. The stage of the cell cycle and the concentrations used are critical for these effects. The addition of isopentenyladenosine within the first 12 hours after phytohemagglutinin at a concentration above 10-6 molar results in inhibition, while lower concentrations (between 10 -7 and 10-6 molar), added at 24 hours or later, have a stimulatory effect.
原文英語
頁(從 - 到)400-402
頁數3
期刊Science
165
發行號3891
出版狀態已發佈 - 十二月 1 1969
對外發佈Yes

ASJC Scopus subject areas

  • General

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