Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella sp

Kuei Hung Lai, Zheng Hao Huang, Mohamed El-Shazly, Bo Rong Peng, Wen Chi Wei, Jui Hsin Su

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

The marine sponge of the genus Geodia, Jaspis, Rhabdastrella, and Stelletta are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to their profound anti-proliferative properties. Further research on exploring its chemical diversity led to the identifications of two new isomalabaricane-type triterpenes rhabdastin H (1) and rhabdastin I (2). Their structures were unraveled using a series of spectroscopic approaches. These isolates were found to exhibit unique structural features with the only reported tetrahydrofuran functionality among all marine-derived isomalabaricanes. Both compounds 1 and 2 showed activities against K562 (IC50 11.7 and 9.8 μM) and Molt4 (IC50 16.5 and 11.0 μM) leukemic cells in MTT cell proliferative assay.
原文英語
期刊Marine Drugs
19
發行號4
DOIs
出版狀態已發佈 - 4月 6 2021

ASJC Scopus subject areas

  • 藥物發現

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