Isoliquiritigenin ameliorates advanced glycation end-products toxicity on renal proximal tubular epithelial cells

Chin Yi Lin, Yu Cheng Lin, Catherine Reena Paul, Dennis Jine Yuan Hsieh, Cecilia Hsuan Day, Ray Jade Chen, Chia Hua Kuo, Tsung Jung Ho, Marthandam Asokan Shibu, Chin Hu Lai, Tzu Ching Shih, Wei Wen Kuo, Chih Yang Huang

研究成果: 雜誌貢獻文章同行評審

摘要

Diabetic nephropathy is a serious chronic complication affecting at least 25% of diabetic patients. Hyperglycemia associated advanced glycation end-products (AGEs) increase tubular epithelial-myofibroblast transdifferentiation (TEMT) and extracellular matrix synthesis and thereby causes renal fibrosis. The chalcone isoliquiritigenin, found in many herbs of Glycyrrhiza family, is known for potential health-promoting effects. However, their effects on AGE-associated renal proximal tubular fibrosis are not known yet. In this study, the effect of isoliquiritigenin on AGE-induced renal proximal tubular fibrosis was determined in cultured HK-2 cell line. The results show that 200 μg/mL of AGE-induced TEMT and the formed myofibroblasts synthesized collagen to increase extracellular matrix formation thereby lead to renal tubular fibrosis. However, treatment with 200 nM of isoliquiritigenin considerably inhibited the TEMT and suppressed the TGFβ/STAT3 mechanism to inhibit collagen secretion. Therefore, isoliquiritigenin effectively suppressed AGE-induced renal tubular fibrosis.

原文英語
頁(從 - 到)2096-2102
頁數7
期刊Environmental Toxicology
37
發行號8
DOIs
出版狀態接受/付印 - 2022

ASJC Scopus subject areas

  • 毒理學
  • 管理、監督、政策法律
  • 健康、毒理學和誘變

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