Isolation and synthesis of a bioactive benzenoid derivative from the fruiting bodies of Antrodia camphorata

Pi Yu Chen, Jen Der Wu, Kai Yih Tang, Chieh Chou Yu, Yueh Hsiung Kuo, Wen-Bin Zhong, Ching Kuo Lee

研究成果: 雜誌貢獻文章

5 引文 (Scopus)

摘要

A new enynyl-benzenoid, antrocamphin O (1,4,7-dimethoxy-5-methyl-6-(3'- methylbut-3-en-1-ynyl)benzo[d][1,3]dioxide), and the known benzenoids antrocamphin A and 7-dimethoxy-5-methyl-1,3-benzodioxole, were isolated from the fruiting bodies of Antrodia camphorata (Taiwanofungus camphoratus). The structure of antrocamphin O was unambiguously assigned by the analysis of spectral data (including 1D and 2D NMR, high-resolution MS, IR, and UV) and total synthesis. Compound 1 was prepared through the Sonogashira reaction of 5-iodo-4,7-dimethoxy-6-methylbenzene and 2-methylbut-1-en-3-yne as the key step. The benzenoids were tested for cytotoxicity against the HT29, HTC15, DLD-1, and COLO 205 colon cancer cell lines, and activities are reported herein.
原文英語
頁(從 - 到)7600-7608
頁數9
期刊Molecules
18
發行號7
DOIs
出版狀態已發佈 - 七月 2013

指紋

Antrodia
activity (biology)
dioxides
cultured cells
isolation
cancer
Derivatives
nuclear magnetic resonance
high resolution
synthesis
Cytotoxicity
Colonic Neoplasms
Cells
Nuclear magnetic resonance
Cell Line
antrocamphin O

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

引用此文

Isolation and synthesis of a bioactive benzenoid derivative from the fruiting bodies of Antrodia camphorata. / Chen, Pi Yu; Wu, Jen Der; Tang, Kai Yih; Yu, Chieh Chou; Kuo, Yueh Hsiung; Zhong, Wen-Bin; Lee, Ching Kuo.

於: Molecules, 卷 18, 編號 7, 07.2013, p. 7600-7608.

研究成果: 雜誌貢獻文章

Chen, Pi Yu ; Wu, Jen Der ; Tang, Kai Yih ; Yu, Chieh Chou ; Kuo, Yueh Hsiung ; Zhong, Wen-Bin ; Lee, Ching Kuo. / Isolation and synthesis of a bioactive benzenoid derivative from the fruiting bodies of Antrodia camphorata. 於: Molecules. 2013 ; 卷 18, 編號 7. 頁 7600-7608.
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abstract = "A new enynyl-benzenoid, antrocamphin O (1,4,7-dimethoxy-5-methyl-6-(3'- methylbut-3-en-1-ynyl)benzo[d][1,3]dioxide), and the known benzenoids antrocamphin A and 7-dimethoxy-5-methyl-1,3-benzodioxole, were isolated from the fruiting bodies of Antrodia camphorata (Taiwanofungus camphoratus). The structure of antrocamphin O was unambiguously assigned by the analysis of spectral data (including 1D and 2D NMR, high-resolution MS, IR, and UV) and total synthesis. Compound 1 was prepared through the Sonogashira reaction of 5-iodo-4,7-dimethoxy-6-methylbenzene and 2-methylbut-1-en-3-yne as the key step. The benzenoids were tested for cytotoxicity against the HT29, HTC15, DLD-1, and COLO 205 colon cancer cell lines, and activities are reported herein.",
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AU - Zhong, Wen-Bin

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N2 - A new enynyl-benzenoid, antrocamphin O (1,4,7-dimethoxy-5-methyl-6-(3'- methylbut-3-en-1-ynyl)benzo[d][1,3]dioxide), and the known benzenoids antrocamphin A and 7-dimethoxy-5-methyl-1,3-benzodioxole, were isolated from the fruiting bodies of Antrodia camphorata (Taiwanofungus camphoratus). The structure of antrocamphin O was unambiguously assigned by the analysis of spectral data (including 1D and 2D NMR, high-resolution MS, IR, and UV) and total synthesis. Compound 1 was prepared through the Sonogashira reaction of 5-iodo-4,7-dimethoxy-6-methylbenzene and 2-methylbut-1-en-3-yne as the key step. The benzenoids were tested for cytotoxicity against the HT29, HTC15, DLD-1, and COLO 205 colon cancer cell lines, and activities are reported herein.

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KW - Enynyl-benzenoid

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