Isolation and synthesis of a bioactive benzenoid derivative from the fruiting bodies of Antrodia camphorata

Pi Yu Chen, Jen Der Wu, Kai Yih Tang, Chieh Chou Yu, Yueh Hsiung Kuo, Wen-Bin Zhong, Ching Kuo Lee

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

摘要

A new enynyl-benzenoid, antrocamphin O (1,4,7-dimethoxy-5-methyl-6-(3'- methylbut-3-en-1-ynyl)benzo[d][1,3]dioxide), and the known benzenoids antrocamphin A and 7-dimethoxy-5-methyl-1,3-benzodioxole, were isolated from the fruiting bodies of Antrodia camphorata (Taiwanofungus camphoratus). The structure of antrocamphin O was unambiguously assigned by the analysis of spectral data (including 1D and 2D NMR, high-resolution MS, IR, and UV) and total synthesis. Compound 1 was prepared through the Sonogashira reaction of 5-iodo-4,7-dimethoxy-6-methylbenzene and 2-methylbut-1-en-3-yne as the key step. The benzenoids were tested for cytotoxicity against the HT29, HTC15, DLD-1, and COLO 205 colon cancer cell lines, and activities are reported herein.
原文英語
頁(從 - 到)7600-7608
頁數9
期刊Molecules
18
發行號7
DOIs
出版狀態已發佈 - 七月 2013

    指紋

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

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