Isolation and immunomodulatory effect of homoisoflavones and flavones from Agave sisalana Perrine Ex Engelm

Pi Yu Chen, Yuh Chi Kuo, Chin Hui Chen, Yueh Hsiung Kuo, Ching Kuo Lee

研究成果: 雜誌貢獻文章

32 引文 (Scopus)

摘要

Three known flavones and seven known homoisoflavonoids were isolated from the methanolic extract of the leaves of Agave sisalana Perrine ex Engelm. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were also evaluated for immunopharmacological activity. PBMC were used as target cells, and cell proliferation was determined by 3H- thymidine uptake. (±)-3,9-Dihydroeucomin (4), dihydrobonducellin (5), and 5,7-dihydroxy-3-(4′-hydroxybenzyl)-4-chromanone (7) showed inhibitory effects on PBMC proliferation activated by PHA with IC50 values 19.4, 73.8, and 58.8 μM, respectively. All three compounds significantly inhibited the production of IL-2 and IFN-γ in activated PBMC in a concentration-dependent manner.

原文英語
頁(從 - 到)1789-1795
頁數7
期刊Molecules
14
發行號5
DOIs
出版狀態已發佈 - 五月 2009

指紋

Agave
Flavones
thymidine
Isoflavones
Spectroscopic analysis
Cell proliferation
spectroscopic analysis
Thymidine
leaves
Inhibitory Concentration 50
Interleukin-2
isolation
Cell Proliferation
cells
4-chromanone
dihydrobonducellin

ASJC Scopus subject areas

  • Organic Chemistry

引用此文

Isolation and immunomodulatory effect of homoisoflavones and flavones from Agave sisalana Perrine Ex Engelm. / Chen, Pi Yu; Kuo, Yuh Chi; Chen, Chin Hui; Kuo, Yueh Hsiung; Lee, Ching Kuo.

於: Molecules, 卷 14, 編號 5, 05.2009, p. 1789-1795.

研究成果: 雜誌貢獻文章

Chen, Pi Yu ; Kuo, Yuh Chi ; Chen, Chin Hui ; Kuo, Yueh Hsiung ; Lee, Ching Kuo. / Isolation and immunomodulatory effect of homoisoflavones and flavones from Agave sisalana Perrine Ex Engelm. 於: Molecules. 2009 ; 卷 14, 編號 5. 頁 1789-1795.
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