摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 337-343 |
| 頁數 | 7 |
| 期刊 | Neuro-Ophthalmology Japan |
| 卷 | 27 |
| 發行號 | 3 |
| 出版狀態 | 已發佈 - 九月 1 2010 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Ophthalmology
- Clinical Neurology
引用此文
Isolated paraneoplastic optic neuropathy associated with acute lymphoblastic leukemia and collapsin response-mediating protein (CRMP-5) autoantibody. / Huang, Tzu Lun; Kao, Ruey Ho; Lin, Yih Chun; Tsai, Rong Kung.
於: Neuro-Ophthalmology Japan, 卷 27, 編號 3, 01.09.2010, p. 337-343.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Isolated paraneoplastic optic neuropathy associated with acute lymphoblastic leukemia and collapsin response-mediating protein (CRMP-5) autoantibody
AU - Huang, Tzu Lun
AU - Kao, Ruey Ho
AU - Lin, Yih Chun
AU - Tsai, Rong Kung
PY - 2010/9/1
Y1 - 2010/9/1
N2 - We present a patient with leukemia associated with a CRMP-5-related paraneoplastic optic neuropathy (PON). A 30-year-old man with acute lymphoblastic leukemia (ALL) and complete chemotherapy suffered from a subacute painless visual loss in both eyes. His vision progressively decreased to 20/300 (OD) and 20/2000 (OS), respectively. Fundoscopy showed a massive disc edema (OS). Autoperimetry demonstrated generalized depression in both eyes. Magnetic resonance imaging (MRI) revealed swelling of left optic nerve at the orbital apex. Lumbar puncture examinations revealed a normal intracranial pressure and without tumor cell infiltration. CSF and serum for autoantibody examinations by using western blot showed a positive reaction to CRMP-5, but negative in myelin, voltage-dependent calcium channel alpha 1 (CACNA1), enolase and recoverin. Repeated lumbar puncture revealed a few immature myelomonocytic cells in CSF. Intravenous pulse therapy with Solu-Medrol associated with chemotherapy was administrated, the vision recovered to 20/40 (OD) and 20/60 (OS) within three days. One month later, his vision recovered to 20/20 (OD) and 20/30 (OS), as well as disc edema in left eye completely resolved. Paraneoplastic optic neuropathy should be in the differential considerations of disc edema in patients with malignancy.
AB - We present a patient with leukemia associated with a CRMP-5-related paraneoplastic optic neuropathy (PON). A 30-year-old man with acute lymphoblastic leukemia (ALL) and complete chemotherapy suffered from a subacute painless visual loss in both eyes. His vision progressively decreased to 20/300 (OD) and 20/2000 (OS), respectively. Fundoscopy showed a massive disc edema (OS). Autoperimetry demonstrated generalized depression in both eyes. Magnetic resonance imaging (MRI) revealed swelling of left optic nerve at the orbital apex. Lumbar puncture examinations revealed a normal intracranial pressure and without tumor cell infiltration. CSF and serum for autoantibody examinations by using western blot showed a positive reaction to CRMP-5, but negative in myelin, voltage-dependent calcium channel alpha 1 (CACNA1), enolase and recoverin. Repeated lumbar puncture revealed a few immature myelomonocytic cells in CSF. Intravenous pulse therapy with Solu-Medrol associated with chemotherapy was administrated, the vision recovered to 20/40 (OD) and 20/60 (OS) within three days. One month later, his vision recovered to 20/20 (OD) and 20/30 (OS), as well as disc edema in left eye completely resolved. Paraneoplastic optic neuropathy should be in the differential considerations of disc edema in patients with malignancy.
KW - Acute lymphoblastic leukemia
KW - CRMP-5
KW - Paraneoplastic optic neuropathy
UR - http://www.scopus.com/inward/record.url?scp=78649430532&partnerID=8YFLogxK
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M3 - Article
VL - 27
SP - 337
EP - 343
JO - Neuro-Ophthalmology Japan
JF - Neuro-Ophthalmology Japan
SN - 0289-7024
IS - 3
ER -