Is the timing of implantation affected by Zona pellucida micromanipulation?

Ming I. Hsu, Gerardo Barroso, Jacob Mayer, Susan Lanzendorf, William E. Gibbons, Suheil Muasher, Sergio Oehninger

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)


Purpose: Our purpose was to examine the timing of implantation and early embryo development following uterine transfer of oocytes/embryos previously subjected to zona pellucida micromanipulation. Methods: A total of 68 singleton pregnancies resulting from IVF and embryo transfer with/without micromanipulation. Patients were divided into four groups according to the type of micromanipulation technique: assisted hatching, embryo biopsy, intracytoplasmic sperm injection, and no micromanipulation (control group). Serial serum β-hCG levels were measured between 10 and 25 days after fertilization and log-transformed. Linear regression analyses were performed and extrapolated to hCG = 10 mlU/ml (hCG10) to estimate detectable implantation. The slopes of the regression lines were used to estimate the rising speed of hCG, an indirect sign of embryo development. Results: There were no significant differences among groups with respect to hCG10, the slopes or intercepts of the regression lines. Conclusions: Various oocyte/embryo microsurgical procedures used in ART involving zona pellucida manipulation do not appear to affect the timing of implantation or early embryo development.

頁(從 - 到)34-38
期刊Journal of Assisted Reproduction and Genetics
出版狀態已發佈 - 2000

ASJC Scopus subject areas

  • 婦產科
  • 發展生物學
  • 遺傳學
  • 生殖醫學


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