Is the endogenous peroxyl-radical scavenging capacity of plasma protective in systemic inflammatory disorders in humans?

Kelvin Tsai, Tai Ger Hsu, Chi Woon Kong, Kuan Chia Lin, L. U. Fung-Jou

研究成果: 雜誌貢獻文章同行評審

59 引文 斯高帕斯(Scopus)

摘要

Systemic inflammatory response syndrome (SIRS) in humans is associated with heightened intravascular oxidative stress. The clinical significance of plasma endogenous antioxidative capability in SIRS remains undetermined. Time-sequence changes of plasma total radical-trapping antioxidant parameter (TRAP) and its components were measured in 135 patients with various clinical conditions leading to SIRS. The results were correlated with clinical parameters. Plasma TRAP significantly depressed upon diagnosis of SIRS (SIRS vs. healthy subjects (n = 50), 605.7 ± 20.4 vs. 803.4 ± 30.8 μM Trolox equivalent, p < .001). In survivors (n = 86), TRAP declined further during the course of SIRS, followed by a mild recovery at the end of follow-up. General linear mixed model analysis revealed that uric acid, vitamin C, vitamin E and unidentified antioxidants contributed to most of the changes in TRAP (each factor p < .001). In nonsurvivors (n = 49), TRAP increased steadily until death, and the increase was predominantly the result of the increased contribution of bilirubin (p < .01). Higher TRAP levels were not correlated with diminished blood oxidants formation (r = -0.13, p > .05), lower intensity of lipid peroxidation (r = 0.261, p < .05) or lesser disease severity of SIRS. The results do not support the hypothesis that the endogenous peroxyl radical scavenging ability of plasma plays a protective role in the course of SIRS. Copyright (C) 2000 Elsevier Science Inc.
原文英語
頁(從 - 到)926-933
頁數8
期刊Free Radical Biology and Medicine
28
發行號6
DOIs
出版狀態已發佈 - 三月 15 2000
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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