Is subcortical-cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach

Antonio Alcaro, Jaak Panksepp, Jan Witczak, Dave J. Hayes, Georg Northoff

研究成果: 雜誌貢獻文章同行評審

115 引文 斯高帕斯(Scopus)

摘要

Major depressive disorder has recently been characterized by abnormal resting state hyperactivity in anterior midline regions. The neurochemical mechanisms underlying resting state hyperactivity remain unclear. Since animal studies provide an opportunity to investigate subcortical regions and neurochemical mechanisms in more detail, we used a cross-species translational approach comparing a meta-analysis of human data to animal data on the functional anatomy and neurochemical modulation of resting state activity in depression. Animal and human data converged in showing resting state hyperactivity in various ventral midline regions. These were also characterized by abnormal concentrations of glutamate and γ-aminobutyric acid (GABA) as well as by NMDA receptor up-regulation and AMPA and GABA receptor down-regulation. This cross-species translational investigation suggests that resting state hyperactivity in depression occurs in subcortical and cortical midline regions and is mediated by glutamate and GABA metabolism. This provides insight into the biochemical underpinnings of resting state activity in both depressed and healthy subjects.
原文英語
頁(從 - 到)592-605
頁數14
期刊Neuroscience and Biobehavioral Reviews
34
發行號4
DOIs
出版狀態已發佈 - 3月 2010
對外發佈

ASJC Scopus subject areas

  • 行為神經科學
  • 認知神經科學
  • 神經心理學與生理心理學

指紋

深入研究「Is subcortical-cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach」主題。共同形成了獨特的指紋。

引用此