Is a boosting dose of granulocyte-colony-stimulating factor necessary for healthy PBSC donors undergoing secondary apheresis? An institute's experience

Shu Huey Chen, Chi Jui Lu, Shu Hui Wen, Ya Jun Zheng, Shang Hsien Yang, Yu Chieh Su, Dian Kun Li

研究成果: 雜誌貢獻文章

摘要

Successful allogeneic PBSC transplantation depends upon the infusion of an adequate number of CD34+ cells to patients. Granulocyte-colony-stimulating factors (G-CSF) mobilized PBSC were harvested on 5th day after stimulation from donors. When the CD34+ cell target yield was not achieved; secondary apheresis was performed the following day. Before September 2006, 67 donors (Group A) received five doses of G-CSF. After September 2006, a sixth dose of G-CSF was administered to 35 donors (Group B) to improve CD34+ yield. The mean CD34+-cell concentration of the second PBSC harvest was significantly higher in Group B (1,087 × 106/l vs. 767 × 106/l; P = 0.031).

原文英語
頁(從 - 到)87-90
頁數4
期刊Transfusion and Apheresis Science
40
發行號2
DOIs
出版狀態已發佈 - 四月 2009
對外發佈Yes

ASJC Scopus subject areas

  • Hematology

指紋 深入研究「Is a boosting dose of granulocyte-colony-stimulating factor necessary for healthy PBSC donors undergoing secondary apheresis? An institute's experience」主題。共同形成了獨特的指紋。

  • 引用此