Iridium Oxide Nanoparticle–Protein Corona Neural Interfaces with Enhanced Electroactivity and Bioactivity Enable Electrically Manipulatable Physical and Chemical Neuronal Activation

Fu Erh Chan, Huei Min Syu, Te Yi Wang, Zheng Ting Tang, Chih Ning Huang, Jyh Fu Lee, Thierry Burnouf, Shang Hsiu Hu, Po Chun Chen, Wei Chen Huang

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Iridium oxide (IrOx) is a promising implantable electrode material owing to its remarkable neural stimulation capacity. However, presently, IrOx electrodes lack biocompatibility and bioactive interactions with nerve tissues. Application of polymeric surface coatings results in a weak physical adhesion at the organic/inorganic interface, which limits their wide-scale application. Herein, a smart iridium oxide-plasma protein (IrOx-PP) electrode with enhanced electroactivity, electrochemical stability, cytocompatibility, and bioactivity that can provide controllable topographical, electrical, and chemical stimuli to enhance neuronal activity is proposed. In the inorganic/organic nanoparticle (NP)-protein corona structures, the soft NP-corona led to repeated burst-to-zero-to-burst PP release, while the hard NP-corona with an ordered atomic structure enhanced the electrochemical stability and bioactivity. The incorporated PP resulted in a higher current storage capacity, lower impedance, better cell growth, and significant neurite outgrowth compared with those obtained with pristine IrOx. The application of electrical stimulation to IrOx-PP enabled simultaneous neuromodulation, on-demand PP release, and cell uptake, with a 2-fold higher cell density and significant neurite outgrowth on IrOx-PP than on pristine IrOx. This bioactive inorganic-organic hybrid electrode with the combined features of physical properties and improved neuromodulation is expected to be a revolutionary platform for efficient and biocompatible neural implantation.
原文英語
文章編號2100694
期刊Advanced Materials Interfaces
8
發行號16
DOIs
出版狀態已發佈 - 8月 23 2021

ASJC Scopus subject areas

  • 材料力學
  • 機械工業

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