Involvement of F-actin in chaperonin-containing t-complex 1 beta regulating mouse mesangial cell functions in a glucose-induction cell model

Jin Shuen Chen, Li Chien Chang, Chia Chao Wu, Lai King Yeung, Yuh Feng Lin

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4 引文 斯高帕斯(Scopus)

摘要

The aim of this study is to investigate the role of chaperonin-containing t-complex polypeptide 1 beta (CCT2) in the regulation of mouse mesangial cell (mMC) contraction, proliferation, and migration with filamentous/globular-(F/G-) actin ratio under high glucose induction. A low CCT2mMC model induced by treatment of small interference RNA was established. Groups with and without low CCT2 induction examined in normal and high (H) glucose conditions revealed the following major results: (1) low CCT2 or H glucose showed the ability to attenuate F/G-actin ratio; (2) groups with low F/G-actin ratio all showed less cell contraction; (3) suppression of CCT2 may reduce the proliferation and migration which were originally induced by H glucose. In conclusion, CCT2 can be used as a specific regulator for mMC contraction, proliferation, and migration affected by glucose, which mechanism may involve the alteration of F-actin, particularly for cell contraction.

原文英語
文章編號565647
期刊Experimental Diabetes Research
2011
DOIs
出版狀態已發佈 - 2011

ASJC Scopus subject areas

  • 醫藥 (全部)
  • 內分泌學、糖尿病和代謝
  • 音樂

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