摘要
To explore the mode of the locomotor stimulant action of thyrotropin-releasing hormone (TRH), rats with or without administration of opiate or catecholaminergic receptor antagonists were infused with TRH through previously implanted hypothalamic cannula. Administration of TRH, but not the normal saline or TSH, into the ventromedial hypothalamus caused an enhancement in both the gross movements (including stimulation of forward locomotion, head and body rearing) and fine movements (including increased grooming and head swaying). The locomotor stimulant action provoked by TRH was antagonized by pretreatment of ventromedial hypothalamus with either an alpha-adrenergic receptor antagonist (yohimbine), a dopaminergic receptor antagonist (haloperidol) or an opiate receptor antagonist (naloxone), but not with a beta-adrenergic receptor antagonist (propranolol). The results indicate that all the adrenergic, dopaminergic and opiate receptors in the ventromedial hypothalamus are involved in the TRH-induced hyperactivity in the rat.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 217-225 |
| 頁數 | 9 |
| 期刊 | Journal of Neural Transmission |
| 卷 | 68 |
| 發行號 | 3-4 |
| DOIs | |
| 出版狀態 | 已發佈 - 九月 1987 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Neuroscience(all)
- Medicine(all)
引用此文
Involvement of both opiate and catecholaminergic receptors of ventromedial hypothalamus in the locomotor stimulant action of thyrotropin-releasing hormone. / Lin, L. S.; Chiu, W. T.; Shih, C. J.; Lin, M. T.
於: Journal of Neural Transmission, 卷 68, 編號 3-4, 09.1987, p. 217-225.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Involvement of both opiate and catecholaminergic receptors of ventromedial hypothalamus in the locomotor stimulant action of thyrotropin-releasing hormone
AU - Lin, L. S.
AU - Chiu, W. T.
AU - Shih, C. J.
AU - Lin, M. T.
PY - 1987/9
Y1 - 1987/9
N2 - To explore the mode of the locomotor stimulant action of thyrotropin-releasing hormone (TRH), rats with or without administration of opiate or catecholaminergic receptor antagonists were infused with TRH through previously implanted hypothalamic cannula. Administration of TRH, but not the normal saline or TSH, into the ventromedial hypothalamus caused an enhancement in both the gross movements (including stimulation of forward locomotion, head and body rearing) and fine movements (including increased grooming and head swaying). The locomotor stimulant action provoked by TRH was antagonized by pretreatment of ventromedial hypothalamus with either an alpha-adrenergic receptor antagonist (yohimbine), a dopaminergic receptor antagonist (haloperidol) or an opiate receptor antagonist (naloxone), but not with a beta-adrenergic receptor antagonist (propranolol). The results indicate that all the adrenergic, dopaminergic and opiate receptors in the ventromedial hypothalamus are involved in the TRH-induced hyperactivity in the rat.
AB - To explore the mode of the locomotor stimulant action of thyrotropin-releasing hormone (TRH), rats with or without administration of opiate or catecholaminergic receptor antagonists were infused with TRH through previously implanted hypothalamic cannula. Administration of TRH, but not the normal saline or TSH, into the ventromedial hypothalamus caused an enhancement in both the gross movements (including stimulation of forward locomotion, head and body rearing) and fine movements (including increased grooming and head swaying). The locomotor stimulant action provoked by TRH was antagonized by pretreatment of ventromedial hypothalamus with either an alpha-adrenergic receptor antagonist (yohimbine), a dopaminergic receptor antagonist (haloperidol) or an opiate receptor antagonist (naloxone), but not with a beta-adrenergic receptor antagonist (propranolol). The results indicate that all the adrenergic, dopaminergic and opiate receptors in the ventromedial hypothalamus are involved in the TRH-induced hyperactivity in the rat.
KW - adrenergic receptors
KW - dopaminergic receptors
KW - Locomotor activity
KW - opiate receptors
KW - thyrotropin-releasing hormone
KW - ventromedial hypothalamus
UR - http://www.scopus.com/inward/record.url?scp=0023102963&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023102963&partnerID=8YFLogxK
U2 - 10.1007/BF02098499
DO - 10.1007/BF02098499
M3 - Article
C2 - 3031208
AN - SCOPUS:0023102963
VL - 68
SP - 217
EP - 225
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
SN - 0300-9564
IS - 3-4
ER -