Investigation of bone growth in additive-manufactured pedicle screw implant by using Ti-6Al-4V and bioactive glass powder composite

Tu Ngoc Lam, Minh Giam Trinh, Chih Chieh Huang, Pei Ching Kung, Wei Chin Huang, Wei Chang, Lia Amalia, Hsu Hsuan Chin, Nien Ti Tsou, Shao Ju Shih, San Yuan Chen, Chun Chieh Wang, Pei I. Tsai, Meng Huang Wu, E. Wen Huang

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2 引文 斯高帕斯(Scopus)

摘要

In this study, we optimized the geometry and composition of additive-manufactured pedicle screws. Metal powders of titanium-aluminum-vanadium (Ti-6Al-4V) were mixed with reactive glass-ceramic biomaterials of bioactive glass (BG) powders. To optimize the geometry of pedicle screws, we applied a novel numerical approach to proposing the optimal shape of the healing chamber to promote biological healing. We examined the geometry and composition effects of pedicle screw implants on the interfacial autologous bone attachment and bone graft incorporation through in vivo studies. The addition of an optimal amount of BG to Ti-6Al-4V leads to a lower elastic modulus of the ceramic-metal composite material, effectively reducing the stress-shielding effects. Pedicle screw implants with optimal shape design and made of the composite material of Ti-6Al-4V doped with BG fabricated through additive manufacturing exhibit greater osseointegration and a more rapid bone volume fraction during the fracture healing process 120 days after implantation, per in vivo studies.
原文英語
文章編號7438
頁(從 - 到)1-13
頁數13
期刊International journal of molecular sciences
21
發行號20
DOIs
出版狀態已發佈 - 十月 2 2020

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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