Investigation of antiulcer activities of imidazo[1,2-α]pyridinyl-2-alkylaminobenzoxazoles and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles with electron-topological (ET) method

Hsu Shan Huang, Jeng Fong Chiou, Hui Fen Chiu, Rong Fu Chen, Yu Liang Lai

研究成果: 雜誌貢獻文章

摘要

The study presents structure-activity considerations of a series of imidazo[1,2-α]pyridiny-2-alkylaminobenzoxazoles(I) and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles (II) investigated for anti-stress ulcer activity with the electron-topological method. A series of 39 compounds including 24 active and 15 weakly active was studied. It is shown that the fragment determined by the electron-topological method in an active molecule is responsible for anti-stress ulcer activity. Quantitative structure-activity relationships with electron topological approach of these compounds are discussed in terms of the statistical program STATGRAF-7.0.
原文英語
頁(從 - 到)27-32
頁數6
期刊Archiv der Pharmazie
335
發行號1
DOIs
出版狀態已發佈 - 2002

指紋

Electrons
Ulcer
Quantitative Structure-Activity Relationship
Molecules
2-alkylaminobenzoxazole
N-dodecyl-L-lysine amide

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

引用此文

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title = "Investigation of antiulcer activities of imidazo[1,2-α]pyridinyl-2-alkylaminobenzoxazoles and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles with electron-topological (ET) method",
abstract = "The study presents structure-activity considerations of a series of imidazo[1,2-α]pyridiny-2-alkylaminobenzoxazoles(I) and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles (II) investigated for anti-stress ulcer activity with the electron-topological method. A series of 39 compounds including 24 active and 15 weakly active was studied. It is shown that the fragment determined by the electron-topological method in an active molecule is responsible for anti-stress ulcer activity. Quantitative structure-activity relationships with electron topological approach of these compounds are discussed in terms of the statistical program STATGRAF-7.0.",
keywords = "Antiulcer activity, Electronic structure, Structure-activity relationship",
author = "Huang, {Hsu Shan} and Chiou, {Jeng Fong} and Chiu, {Hui Fen} and Chen, {Rong Fu} and Lai, {Yu Liang}",
year = "2002",
doi = "10.1002/1521-4184(200201)335:1<27::AID-ARDP27>3.0.CO;2-V",
language = "English",
volume = "335",
pages = "27--32",
journal = "Archiv der Pharmazie",
issn = "0365-6233",
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TY - JOUR

T1 - Investigation of antiulcer activities of imidazo[1,2-α]pyridinyl-2-alkylaminobenzoxazoles and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles with electron-topological (ET) method

AU - Huang, Hsu Shan

AU - Chiou, Jeng Fong

AU - Chiu, Hui Fen

AU - Chen, Rong Fu

AU - Lai, Yu Liang

PY - 2002

Y1 - 2002

N2 - The study presents structure-activity considerations of a series of imidazo[1,2-α]pyridiny-2-alkylaminobenzoxazoles(I) and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles (II) investigated for anti-stress ulcer activity with the electron-topological method. A series of 39 compounds including 24 active and 15 weakly active was studied. It is shown that the fragment determined by the electron-topological method in an active molecule is responsible for anti-stress ulcer activity. Quantitative structure-activity relationships with electron topological approach of these compounds are discussed in terms of the statistical program STATGRAF-7.0.

AB - The study presents structure-activity considerations of a series of imidazo[1,2-α]pyridiny-2-alkylaminobenzoxazoles(I) and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles (II) investigated for anti-stress ulcer activity with the electron-topological method. A series of 39 compounds including 24 active and 15 weakly active was studied. It is shown that the fragment determined by the electron-topological method in an active molecule is responsible for anti-stress ulcer activity. Quantitative structure-activity relationships with electron topological approach of these compounds are discussed in terms of the statistical program STATGRAF-7.0.

KW - Antiulcer activity

KW - Electronic structure

KW - Structure-activity relationship

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U2 - 10.1002/1521-4184(200201)335:1<27::AID-ARDP27>3.0.CO;2-V

DO - 10.1002/1521-4184(200201)335:1<27::AID-ARDP27>3.0.CO;2-V

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JO - Archiv der Pharmazie

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