Investigation of antiulcer activities of imidazo[1,2-α]pyridinyl-2-alkylaminobenzoxazoles and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles with electron-topological (ET) method

Hsu Shan Huang, Jeng Fong Chiou, Hui Fen Chiu, Rong Fu Chen, Yu Liang Lai

研究成果: 雜誌貢獻文章

摘要

The study presents structure-activity considerations of a series of imidazo[1,2-α]pyridiny-2-alkylaminobenzoxazoles(I) and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles (II) investigated for anti-stress ulcer activity with the electron-topological method. A series of 39 compounds including 24 active and 15 weakly active was studied. It is shown that the fragment determined by the electron-topological method in an active molecule is responsible for anti-stress ulcer activity. Quantitative structure-activity relationships with electron topological approach of these compounds are discussed in terms of the statistical program STATGRAF-7.0.
原文英語
頁(從 - 到)27-32
頁數6
期刊Archiv der Pharmazie
335
發行號1
DOIs
出版狀態已發佈 - 2002

    指紋

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

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