摘要

We investigated the effects of nickel oxide nanoparticles (NiONPs) on the pulmonary inflammopathology. NiONPs were intratracheally installed into mice, and lung injury and inflammation were evaluated between 1 and 28 days. NiONPs caused significant increases in LDH, total protein, and IL-6 and a decrease in IL-10 in the BALF and increases in 8-OHdG and caspase-3 in lung tissues at 24 h. Airway inflammation was present in a dose-dependent manner from the upper to lower airways at 24 h of exposure as analyzed by SPECT. Lung parenchyma inflammation and small airway inflammation were observed by CT after NiONP exposure. 8-OHdG in lung tissues had increased with formation of fibrosis at 28 days. Focal adhesion was the most important pathways identified at 24 h as determined by protemics, whereas glutathione metabolism was the most important identified at 28 days. Our results demonstrated the pulmonary inflammopathology caused by NiONPs based on image-to-biochemical approaches.
原文英語
頁(從 - 到)2329-2339
頁數11
期刊Nanomedicine: Nanotechnology, Biology, and Medicine
14
發行號7
DOIs
出版狀態已發佈 - 十月 1 2018

指紋

Nickel oxide
Nanoparticles
Lung
Pneumonia
Tissue
Inflammation
Focal Adhesions
Lung Injury
Single-Photon Emission-Computed Tomography
Metabolism
Caspase 3
Interleukin-10
Glutathione
Interleukin-6
Fibrosis
Adhesion
nickel monoxide
Proteins

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

引用此文

Investigation into the pulmonary inflammopathology of exposure to nickel oxide nanoparticles in mice. / Bai, Kuan Jen; Chuang, Kai Jen; Chen, Jen Kun; Hua, His En; Shen, Yen Ling; Liao, Wei Neng; Lee, Chii Hong; Chen, Kuan Yuan; Lee, Kang Yun; Hsiao, Ta Chih; Pan, Chih Hong; Ho, Kin Fai; Chuang, Hsiao Chi.

於: Nanomedicine: Nanotechnology, Biology, and Medicine, 卷 14, 編號 7, 01.10.2018, p. 2329-2339.

研究成果: 雜誌貢獻文章

Bai, Kuan Jen ; Chuang, Kai Jen ; Chen, Jen Kun ; Hua, His En ; Shen, Yen Ling ; Liao, Wei Neng ; Lee, Chii Hong ; Chen, Kuan Yuan ; Lee, Kang Yun ; Hsiao, Ta Chih ; Pan, Chih Hong ; Ho, Kin Fai ; Chuang, Hsiao Chi. / Investigation into the pulmonary inflammopathology of exposure to nickel oxide nanoparticles in mice. 於: Nanomedicine: Nanotechnology, Biology, and Medicine. 2018 ; 卷 14, 編號 7. 頁 2329-2339.
@article{ffbf71cefce34ab8a926c26c1b5083f5,
title = "Investigation into the pulmonary inflammopathology of exposure to nickel oxide nanoparticles in mice",
abstract = "We investigated the effects of nickel oxide nanoparticles (NiONPs) on the pulmonary inflammopathology. NiONPs were intratracheally installed into mice, and lung injury and inflammation were evaluated between 1 and 28 days. NiONPs caused significant increases in LDH, total protein, and IL-6 and a decrease in IL-10 in the BALF and increases in 8-OHdG and caspase-3 in lung tissues at 24 h. Airway inflammation was present in a dose-dependent manner from the upper to lower airways at 24 h of exposure as analyzed by SPECT. Lung parenchyma inflammation and small airway inflammation were observed by CT after NiONP exposure. 8-OHdG in lung tissues had increased with formation of fibrosis at 28 days. Focal adhesion was the most important pathways identified at 24 h as determined by protemics, whereas glutathione metabolism was the most important identified at 28 days. Our results demonstrated the pulmonary inflammopathology caused by NiONPs based on image-to-biochemical approaches.",
keywords = "Chest computed tomography, Fibrosis, Oxidative stress, Proteomics, Single-photon emission computed tomography",
author = "Bai, {Kuan Jen} and Chuang, {Kai Jen} and Chen, {Jen Kun} and Hua, {His En} and Shen, {Yen Ling} and Liao, {Wei Neng} and Lee, {Chii Hong} and Chen, {Kuan Yuan} and Lee, {Kang Yun} and Hsiao, {Ta Chih} and Pan, {Chih Hong} and Ho, {Kin Fai} and Chuang, {Hsiao Chi}",
year = "2018",
month = "10",
day = "1",
doi = "10.1016/j.nano.2017.10.003",
language = "English",
volume = "14",
pages = "2329--2339",
journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",
issn = "1549-9634",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Investigation into the pulmonary inflammopathology of exposure to nickel oxide nanoparticles in mice

AU - Bai, Kuan Jen

AU - Chuang, Kai Jen

AU - Chen, Jen Kun

AU - Hua, His En

AU - Shen, Yen Ling

AU - Liao, Wei Neng

AU - Lee, Chii Hong

AU - Chen, Kuan Yuan

AU - Lee, Kang Yun

AU - Hsiao, Ta Chih

AU - Pan, Chih Hong

AU - Ho, Kin Fai

AU - Chuang, Hsiao Chi

PY - 2018/10/1

Y1 - 2018/10/1

N2 - We investigated the effects of nickel oxide nanoparticles (NiONPs) on the pulmonary inflammopathology. NiONPs were intratracheally installed into mice, and lung injury and inflammation were evaluated between 1 and 28 days. NiONPs caused significant increases in LDH, total protein, and IL-6 and a decrease in IL-10 in the BALF and increases in 8-OHdG and caspase-3 in lung tissues at 24 h. Airway inflammation was present in a dose-dependent manner from the upper to lower airways at 24 h of exposure as analyzed by SPECT. Lung parenchyma inflammation and small airway inflammation were observed by CT after NiONP exposure. 8-OHdG in lung tissues had increased with formation of fibrosis at 28 days. Focal adhesion was the most important pathways identified at 24 h as determined by protemics, whereas glutathione metabolism was the most important identified at 28 days. Our results demonstrated the pulmonary inflammopathology caused by NiONPs based on image-to-biochemical approaches.

AB - We investigated the effects of nickel oxide nanoparticles (NiONPs) on the pulmonary inflammopathology. NiONPs were intratracheally installed into mice, and lung injury and inflammation were evaluated between 1 and 28 days. NiONPs caused significant increases in LDH, total protein, and IL-6 and a decrease in IL-10 in the BALF and increases in 8-OHdG and caspase-3 in lung tissues at 24 h. Airway inflammation was present in a dose-dependent manner from the upper to lower airways at 24 h of exposure as analyzed by SPECT. Lung parenchyma inflammation and small airway inflammation were observed by CT after NiONP exposure. 8-OHdG in lung tissues had increased with formation of fibrosis at 28 days. Focal adhesion was the most important pathways identified at 24 h as determined by protemics, whereas glutathione metabolism was the most important identified at 28 days. Our results demonstrated the pulmonary inflammopathology caused by NiONPs based on image-to-biochemical approaches.

KW - Chest computed tomography

KW - Fibrosis

KW - Oxidative stress

KW - Proteomics

KW - Single-photon emission computed tomography

UR - http://www.scopus.com/inward/record.url?scp=85035119944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85035119944&partnerID=8YFLogxK

U2 - 10.1016/j.nano.2017.10.003

DO - 10.1016/j.nano.2017.10.003

M3 - Article

VL - 14

SP - 2329

EP - 2339

JO - Nanomedicine: Nanotechnology, Biology, and Medicine

JF - Nanomedicine: Nanotechnology, Biology, and Medicine

SN - 1549-9634

IS - 7

ER -