摘要

Background: This case-control study aimed to find the relationship between prior statin use and head and neck cancer occurrence using a large population-based database. Methods: This study used claims data from the Taiwan Longitudinal Health Insurance Database. We included 5515 patients with head and neck cancer as cases and 5515 propensity score-matched patients without head and neck cancer as controls. Conditional logistic regressions were performed to investigate the relationship between head and neck cancer and prior statin exposure. Results: Of the 11 030 total sampled patients, 16.95% had previously received prescriptions for statins. In addition, statin exposure was found in 15.99% of cases and 17.91% of controls. The logistic regression also revealed that the adjusted odds ratio of prior statin exposure for cases was 0.86 (95% confidence interval: 0.77-0.95) compared to propensity score-matched controls. Conclusion: This study found an inverse association between statin usage and head and neck cancer occurrence.
原文英語
期刊Head and Neck
DOIs
出版狀態已發佈 - 一月 1 2019

指紋

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Head and Neck Neoplasms
Case-Control Studies
Population
Propensity Score
Logistic Models
Databases
Health Insurance
Taiwan
Prescriptions
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Otorhinolaryngology

引用此文

@article{582706ba0bb44a8081f91cbc2c174e5d,
title = "Inverse association between statin use and head and neck cancer: A population-based case-control study in Han population",
abstract = "Background: This case-control study aimed to find the relationship between prior statin use and head and neck cancer occurrence using a large population-based database. Methods: This study used claims data from the Taiwan Longitudinal Health Insurance Database. We included 5515 patients with head and neck cancer as cases and 5515 propensity score-matched patients without head and neck cancer as controls. Conditional logistic regressions were performed to investigate the relationship between head and neck cancer and prior statin exposure. Results: Of the 11 030 total sampled patients, 16.95{\%} had previously received prescriptions for statins. In addition, statin exposure was found in 15.99{\%} of cases and 17.91{\%} of controls. The logistic regression also revealed that the adjusted odds ratio of prior statin exposure for cases was 0.86 (95{\%} confidence interval: 0.77-0.95) compared to propensity score-matched controls. Conclusion: This study found an inverse association between statin usage and head and neck cancer occurrence.",
keywords = "cancer, epidemiology, head and neck cancer, hyperlipidemia, statin",
author = "Kao, {Li Ting} and Hung, {Shih Han} and Kao, {Pai Feng} and Liu, {Ju Chi} and Lin, {Herng Ching}",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/hed.25501",
language = "English",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Inverse association between statin use and head and neck cancer

T2 - A population-based case-control study in Han population

AU - Kao, Li Ting

AU - Hung, Shih Han

AU - Kao, Pai Feng

AU - Liu, Ju Chi

AU - Lin, Herng Ching

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: This case-control study aimed to find the relationship between prior statin use and head and neck cancer occurrence using a large population-based database. Methods: This study used claims data from the Taiwan Longitudinal Health Insurance Database. We included 5515 patients with head and neck cancer as cases and 5515 propensity score-matched patients without head and neck cancer as controls. Conditional logistic regressions were performed to investigate the relationship between head and neck cancer and prior statin exposure. Results: Of the 11 030 total sampled patients, 16.95% had previously received prescriptions for statins. In addition, statin exposure was found in 15.99% of cases and 17.91% of controls. The logistic regression also revealed that the adjusted odds ratio of prior statin exposure for cases was 0.86 (95% confidence interval: 0.77-0.95) compared to propensity score-matched controls. Conclusion: This study found an inverse association between statin usage and head and neck cancer occurrence.

AB - Background: This case-control study aimed to find the relationship between prior statin use and head and neck cancer occurrence using a large population-based database. Methods: This study used claims data from the Taiwan Longitudinal Health Insurance Database. We included 5515 patients with head and neck cancer as cases and 5515 propensity score-matched patients without head and neck cancer as controls. Conditional logistic regressions were performed to investigate the relationship between head and neck cancer and prior statin exposure. Results: Of the 11 030 total sampled patients, 16.95% had previously received prescriptions for statins. In addition, statin exposure was found in 15.99% of cases and 17.91% of controls. The logistic regression also revealed that the adjusted odds ratio of prior statin exposure for cases was 0.86 (95% confidence interval: 0.77-0.95) compared to propensity score-matched controls. Conclusion: This study found an inverse association between statin usage and head and neck cancer occurrence.

KW - cancer

KW - epidemiology

KW - head and neck cancer

KW - hyperlipidemia

KW - statin

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U2 - 10.1002/hed.25501

DO - 10.1002/hed.25501

M3 - Article

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JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

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