Invasive pneumococcal infections: a clinical and microbiological analysis of 53 patients in Taiwan

C-Y. Lee, C-H. Chiu, Y-C. Huang, P-W. Chung, L-H. Su, T-L. Wu, T-Y. Lin

研究成果: 雜誌貢獻文章

12 引文 (Scopus)

摘要

To track penicillin susceptibility among Streptococcus pneumoniae causing invasive diseases and to evaluate risk factors for antibiotic resistance. A retrospective study was performed in a medical center of all patients with invasive pneumococcal infections based on positive microbiological findings, confirmed by appropriate clinical and laboratory findings. MICs of penicillin and ceftriaxone were determined and interpreted by NCCLS methodology. Fifty-three episodes of invasive S. pneumoniae infections (ISPI) among 22 children and 31 adults were identified. The disease patterns of ISPI were similar between children and adults, and the most common modes were pneumonia (70%) and primary bacteremia (23%). The rate of penicillin-nonsusceptible S. pneumoniae (PNSP) isolated from pediatric patients was higher than that in adult patients (95.5% vs. 54.8%, P <0.001). This finding was correlated to prior antibiotic use that was more common in children (36.4%) than in adults (18.9%). The rate of penicillin-resistance among S. pneumoniae isolates (PRSP) was extremely high in this area: 45.5% from pediatric patients and 41.9% from adult patients. More adults (90.3%) with ISPI had major underlying diseases than children (4.5%). This may explain why adult patients tended to run an unfavorable outcome (mortality rate, 51.6% and 4.5% in adults and children, respectively), although most of the cases with empyema were children. None of the patients enrolled in this study received pneumococcal vaccination. We suggest that vaccines be administered for young children and the elderly with major underlying diseases to prevent ISPI.
原文英語
頁(從 - 到)614-618
頁數5
期刊Clinical Microbiology and Infection
9
發行號7
DOIs
出版狀態已發佈 - 2003
對外發佈Yes

指紋

Pneumococcal Infections
Taiwan
Streptococcus pneumoniae
Penicillins
Pediatrics
Penicillin Resistance
Empyema
Ceftriaxone
Microbial Drug Resistance
Bacteremia
Pneumonia
Vaccination
Vaccines
Retrospective Studies
Anti-Bacterial Agents
Mortality

Keywords

  • invasive infection
  • penicillin resistance

引用此文

Invasive pneumococcal infections: a clinical and microbiological analysis of 53 patients in Taiwan. / Lee, C-Y.; Chiu, C-H.; Huang, Y-C.; Chung, P-W.; Su, L-H.; Wu, T-L.; Lin, T-Y.

於: Clinical Microbiology and Infection, 卷 9, 編號 7, 2003, p. 614-618.

研究成果: 雜誌貢獻文章

Lee, C-Y. ; Chiu, C-H. ; Huang, Y-C. ; Chung, P-W. ; Su, L-H. ; Wu, T-L. ; Lin, T-Y. / Invasive pneumococcal infections: a clinical and microbiological analysis of 53 patients in Taiwan. 於: Clinical Microbiology and Infection. 2003 ; 卷 9, 編號 7. 頁 614-618.
@article{b0eeea8644f44dba930272cb1c30eb86,
title = "Invasive pneumococcal infections: a clinical and microbiological analysis of 53 patients in Taiwan",
abstract = "To track penicillin susceptibility among Streptococcus pneumoniae causing invasive diseases and to evaluate risk factors for antibiotic resistance. A retrospective study was performed in a medical center of all patients with invasive pneumococcal infections based on positive microbiological findings, confirmed by appropriate clinical and laboratory findings. MICs of penicillin and ceftriaxone were determined and interpreted by NCCLS methodology. Fifty-three episodes of invasive S. pneumoniae infections (ISPI) among 22 children and 31 adults were identified. The disease patterns of ISPI were similar between children and adults, and the most common modes were pneumonia (70{\%}) and primary bacteremia (23{\%}). The rate of penicillin-nonsusceptible S. pneumoniae (PNSP) isolated from pediatric patients was higher than that in adult patients (95.5{\%} vs. 54.8{\%}, P <0.001). This finding was correlated to prior antibiotic use that was more common in children (36.4{\%}) than in adults (18.9{\%}). The rate of penicillin-resistance among S. pneumoniae isolates (PRSP) was extremely high in this area: 45.5{\%} from pediatric patients and 41.9{\%} from adult patients. More adults (90.3{\%}) with ISPI had major underlying diseases than children (4.5{\%}). This may explain why adult patients tended to run an unfavorable outcome (mortality rate, 51.6{\%} and 4.5{\%} in adults and children, respectively), although most of the cases with empyema were children. None of the patients enrolled in this study received pneumococcal vaccination. We suggest that vaccines be administered for young children and the elderly with major underlying diseases to prevent ISPI.",
keywords = "invasive infection, penicillin resistance",
author = "C-Y. Lee and C-H. Chiu and Y-C. Huang and P-W. Chung and L-H. Su and T-L. Wu and T-Y. Lin",
year = "2003",
doi = "10.1046/j.1469-0691.2003.00589.x",
language = "English",
volume = "9",
pages = "614--618",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "Elsevier Limited",
number = "7",

}

TY - JOUR

T1 - Invasive pneumococcal infections: a clinical and microbiological analysis of 53 patients in Taiwan

AU - Lee, C-Y.

AU - Chiu, C-H.

AU - Huang, Y-C.

AU - Chung, P-W.

AU - Su, L-H.

AU - Wu, T-L.

AU - Lin, T-Y.

PY - 2003

Y1 - 2003

N2 - To track penicillin susceptibility among Streptococcus pneumoniae causing invasive diseases and to evaluate risk factors for antibiotic resistance. A retrospective study was performed in a medical center of all patients with invasive pneumococcal infections based on positive microbiological findings, confirmed by appropriate clinical and laboratory findings. MICs of penicillin and ceftriaxone were determined and interpreted by NCCLS methodology. Fifty-three episodes of invasive S. pneumoniae infections (ISPI) among 22 children and 31 adults were identified. The disease patterns of ISPI were similar between children and adults, and the most common modes were pneumonia (70%) and primary bacteremia (23%). The rate of penicillin-nonsusceptible S. pneumoniae (PNSP) isolated from pediatric patients was higher than that in adult patients (95.5% vs. 54.8%, P <0.001). This finding was correlated to prior antibiotic use that was more common in children (36.4%) than in adults (18.9%). The rate of penicillin-resistance among S. pneumoniae isolates (PRSP) was extremely high in this area: 45.5% from pediatric patients and 41.9% from adult patients. More adults (90.3%) with ISPI had major underlying diseases than children (4.5%). This may explain why adult patients tended to run an unfavorable outcome (mortality rate, 51.6% and 4.5% in adults and children, respectively), although most of the cases with empyema were children. None of the patients enrolled in this study received pneumococcal vaccination. We suggest that vaccines be administered for young children and the elderly with major underlying diseases to prevent ISPI.

AB - To track penicillin susceptibility among Streptococcus pneumoniae causing invasive diseases and to evaluate risk factors for antibiotic resistance. A retrospective study was performed in a medical center of all patients with invasive pneumococcal infections based on positive microbiological findings, confirmed by appropriate clinical and laboratory findings. MICs of penicillin and ceftriaxone were determined and interpreted by NCCLS methodology. Fifty-three episodes of invasive S. pneumoniae infections (ISPI) among 22 children and 31 adults were identified. The disease patterns of ISPI were similar between children and adults, and the most common modes were pneumonia (70%) and primary bacteremia (23%). The rate of penicillin-nonsusceptible S. pneumoniae (PNSP) isolated from pediatric patients was higher than that in adult patients (95.5% vs. 54.8%, P <0.001). This finding was correlated to prior antibiotic use that was more common in children (36.4%) than in adults (18.9%). The rate of penicillin-resistance among S. pneumoniae isolates (PRSP) was extremely high in this area: 45.5% from pediatric patients and 41.9% from adult patients. More adults (90.3%) with ISPI had major underlying diseases than children (4.5%). This may explain why adult patients tended to run an unfavorable outcome (mortality rate, 51.6% and 4.5% in adults and children, respectively), although most of the cases with empyema were children. None of the patients enrolled in this study received pneumococcal vaccination. We suggest that vaccines be administered for young children and the elderly with major underlying diseases to prevent ISPI.

KW - invasive infection

KW - penicillin resistance

U2 - 10.1046/j.1469-0691.2003.00589.x

DO - 10.1046/j.1469-0691.2003.00589.x

M3 - Article

C2 - 12925100

VL - 9

SP - 614

EP - 618

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

IS - 7

ER -