Invasive PLA microneedle fabrication applied to drug delivery system

Hsin Chuan Kuo, Yi Lin, Yung Kang Shen, Sheng Chieh Kang

研究成果: 書貢獻/報告類型會議貢獻

3 引文 (Scopus)

摘要

This study fabricated a novel biodegradable polymer microneedle patch. First, a master microneedle array was fabricated using the micro electro-mechainal system (MEMS) process. Polydimethylsiloxane (PDMS) was then utilized to fabricate the microneedle mold. Finally, the biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated by micro hot embossing. The Taguchi method was applied to identify the optimal process parameters for micro hot embossing the PLA microneedle. The sizes of the original microneedle and that of the PLA microneedle were compared, through the transfor by PDMS mold. Next, a numerical simulation and the skin puncture test were used to confirm the PLA microneedle patch fabrication using the optimal process parameters. During numerical simulations, this study used dynamic finite element software (ANSYS/LSDYNA) to simulate the process of the PLA microneedle being inserted into skin. Based on the mechanical properties of different skin layers and the material failure criterion, insertion force and stress variation during PLA microneedle insertion into skin were determined. In a skin puncture experiment, transepidermal water loss (TEWL) was measured to determine whether the PLA microneedle damaged the stratum corneum and decreased the water protection capacity of skin.
原文英語
主出版物標題2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings
頁面7437-7440
頁數4
DOIs
出版狀態已發佈 - 2011
事件2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Inner Mongolia, 中国
持續時間: 七月 15 2011七月 17 2011

其他

其他2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011
國家中国
城市Inner Mongolia
期間7/15/117/17/11

指紋

Skin
Fabrication
Acids
Biodegradable polymers
Polydimethylsiloxane
Taguchi methods
Computer simulation
Drug Delivery Systems
Water
Mechanical properties
Experiments

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Mechanical Engineering

引用此文

Kuo, H. C., Lin, Y., Shen, Y. K., & Kang, S. C. (2011). Invasive PLA microneedle fabrication applied to drug delivery system. 於 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings (頁 7437-7440). [5988769] https://doi.org/10.1109/MACE.2011.5988769

Invasive PLA microneedle fabrication applied to drug delivery system. / Kuo, Hsin Chuan; Lin, Yi; Shen, Yung Kang; Kang, Sheng Chieh.

2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings. 2011. p. 7437-7440 5988769.

研究成果: 書貢獻/報告類型會議貢獻

Kuo, HC, Lin, Y, Shen, YK & Kang, SC 2011, Invasive PLA microneedle fabrication applied to drug delivery system. 於 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings., 5988769, 頁 7437-7440, 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011, Inner Mongolia, 中国, 7/15/11. https://doi.org/10.1109/MACE.2011.5988769
Kuo HC, Lin Y, Shen YK, Kang SC. Invasive PLA microneedle fabrication applied to drug delivery system. 於 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings. 2011. p. 7437-7440. 5988769 https://doi.org/10.1109/MACE.2011.5988769
Kuo, Hsin Chuan ; Lin, Yi ; Shen, Yung Kang ; Kang, Sheng Chieh. / Invasive PLA microneedle fabrication applied to drug delivery system. 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings. 2011. 頁 7437-7440
@inproceedings{d876d91054a1408a86f8e37418a35427,
title = "Invasive PLA microneedle fabrication applied to drug delivery system",
abstract = "This study fabricated a novel biodegradable polymer microneedle patch. First, a master microneedle array was fabricated using the micro electro-mechainal system (MEMS) process. Polydimethylsiloxane (PDMS) was then utilized to fabricate the microneedle mold. Finally, the biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated by micro hot embossing. The Taguchi method was applied to identify the optimal process parameters for micro hot embossing the PLA microneedle. The sizes of the original microneedle and that of the PLA microneedle were compared, through the transfor by PDMS mold. Next, a numerical simulation and the skin puncture test were used to confirm the PLA microneedle patch fabrication using the optimal process parameters. During numerical simulations, this study used dynamic finite element software (ANSYS/LSDYNA) to simulate the process of the PLA microneedle being inserted into skin. Based on the mechanical properties of different skin layers and the material failure criterion, insertion force and stress variation during PLA microneedle insertion into skin were determined. In a skin puncture experiment, transepidermal water loss (TEWL) was measured to determine whether the PLA microneedle damaged the stratum corneum and decreased the water protection capacity of skin.",
keywords = "Micro hot embossing, Numerical simulation, PLA microneedle, Taguchi method, Transepidermal water loss (TEWL)",
author = "Kuo, {Hsin Chuan} and Yi Lin and Shen, {Yung Kang} and Kang, {Sheng Chieh}",
year = "2011",
doi = "10.1109/MACE.2011.5988769",
language = "English",
isbn = "9781424494392",
pages = "7437--7440",
booktitle = "2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings",

}

TY - GEN

T1 - Invasive PLA microneedle fabrication applied to drug delivery system

AU - Kuo, Hsin Chuan

AU - Lin, Yi

AU - Shen, Yung Kang

AU - Kang, Sheng Chieh

PY - 2011

Y1 - 2011

N2 - This study fabricated a novel biodegradable polymer microneedle patch. First, a master microneedle array was fabricated using the micro electro-mechainal system (MEMS) process. Polydimethylsiloxane (PDMS) was then utilized to fabricate the microneedle mold. Finally, the biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated by micro hot embossing. The Taguchi method was applied to identify the optimal process parameters for micro hot embossing the PLA microneedle. The sizes of the original microneedle and that of the PLA microneedle were compared, through the transfor by PDMS mold. Next, a numerical simulation and the skin puncture test were used to confirm the PLA microneedle patch fabrication using the optimal process parameters. During numerical simulations, this study used dynamic finite element software (ANSYS/LSDYNA) to simulate the process of the PLA microneedle being inserted into skin. Based on the mechanical properties of different skin layers and the material failure criterion, insertion force and stress variation during PLA microneedle insertion into skin were determined. In a skin puncture experiment, transepidermal water loss (TEWL) was measured to determine whether the PLA microneedle damaged the stratum corneum and decreased the water protection capacity of skin.

AB - This study fabricated a novel biodegradable polymer microneedle patch. First, a master microneedle array was fabricated using the micro electro-mechainal system (MEMS) process. Polydimethylsiloxane (PDMS) was then utilized to fabricate the microneedle mold. Finally, the biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated by micro hot embossing. The Taguchi method was applied to identify the optimal process parameters for micro hot embossing the PLA microneedle. The sizes of the original microneedle and that of the PLA microneedle were compared, through the transfor by PDMS mold. Next, a numerical simulation and the skin puncture test were used to confirm the PLA microneedle patch fabrication using the optimal process parameters. During numerical simulations, this study used dynamic finite element software (ANSYS/LSDYNA) to simulate the process of the PLA microneedle being inserted into skin. Based on the mechanical properties of different skin layers and the material failure criterion, insertion force and stress variation during PLA microneedle insertion into skin were determined. In a skin puncture experiment, transepidermal water loss (TEWL) was measured to determine whether the PLA microneedle damaged the stratum corneum and decreased the water protection capacity of skin.

KW - Micro hot embossing

KW - Numerical simulation

KW - PLA microneedle

KW - Taguchi method

KW - Transepidermal water loss (TEWL)

UR - http://www.scopus.com/inward/record.url?scp=80054806075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054806075&partnerID=8YFLogxK

U2 - 10.1109/MACE.2011.5988769

DO - 10.1109/MACE.2011.5988769

M3 - Conference contribution

AN - SCOPUS:80054806075

SN - 9781424494392

SP - 7437

EP - 7440

BT - 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings

ER -