Intravenous amiodarone for prevention of atrial fibrillation after coronary artery bypass grafting

Shih Huang Lee, Che Ming Chang, Ming Jen Lu, Ren Jen Lee, Jun Jack Cheng, Chi Ren Hung, Shih Ann Chen

研究成果: 雜誌貢獻文章同行評審

91 引文 斯高帕斯(Scopus)

摘要

Background. Atrial fibrillation occurs in 10% to 40% of patients who undergo coronary artery bypass grafting. This prospective study assesses the safety and efficacy of low-dose intravenous amiodarone in the prevention of atrial fibrillation after coronary artery bypass grafting. Methods. One hundred forty patients were randomly divided into two groups: an amiodarone group (n = 74) receiving intravenous amiodarone in a loading dose of 150 mg and maintenance dose of 0.4 mg·kg-1·h-1 for 3 days before and 5 days after operation and a control group (n = 76) receiving matching infusions of 5% glucose solution. Results. Atrial fibrillation occurred in 9 (12%) of the amiodarone group patients and in 26 (34%) of the control group patients during hospitalization (p < 0.01). The maximum ventricular rate during atrial fibrillation was significantly slower in the amiodarone group (107 ± 21) than in the control group (138 ± 24 beats per minute, p < 0.01). The duration of atrial fibrillation in the amiodarone group (1.1 ± 1.2 hours) was significantly shorter than that in the control group (3.2 ± 1.3 hours, p = 0.01). The two groups had no significant differences in incidence of major morbidity (8 of 74 versus 8 of 76 in amiodarone and control groups, respectively) or mortality (4 of 74 versus 5 of 76). However, the control group had significantly longer intensive care unit stays (132 ± 24 versus 111 ± 19 hours, p < 0.01). Conclusions. Perioperative low-dose intravenous amiodarone significantly reduces the incidence, ventricular rate, and duration of atrial fibrillation after coronary artery bypass grafting. Furthermore, low-dose intravenous amiodarone is well tolerated and does not increase the risk of intraoperative or postoperative complications. (C) 2000 by The Society of Thoracic Surgeons.

原文英語
頁(從 - 到)157-161
頁數5
期刊Annals of Thoracic Surgery
70
發行號1
DOIs
出版狀態已發佈 - 7月 2000
對外發佈

ASJC Scopus subject areas

  • 手術
  • 肺和呼吸系統醫學
  • 心臟病學與心血管醫學

指紋

深入研究「Intravenous amiodarone for prevention of atrial fibrillation after coronary artery bypass grafting」主題。共同形成了獨特的指紋。

引用此