Intratypic variants of human papillomavirus type 16 and risk of cervical Neoplasia in Taiwan

Ya Ju Chang, Hui Chi Chen, Mei Hung Pan, Bor Heng Lee, San Lin You, Ching Yu Lin, Yi Chun Chou, Chang Yao Hsieh, Yu Juen Cheng, Kai Li Liaw, Ann W. Hsing, Mark Schiffman, Chien Jen Chen

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)


The associations between variants of human papillomavirus (HPV) 16 and risk of cervical neoplasia have been reported, but nucleotide variations of HPV 16 in Asian populations and their association with cervical neoplasia have not been evaluated extensively. During 1991-1992, 11,923 women from seven townships in Taiwan were enrolled. The HPV DNA in cervical cells was detected and genotyped using EasyChip HPV blot. Nucleotide variations in the long control region (LCR), E6, and E7 genes were determined using DNA sequencing for 170 HPV 16-positive cervical samples. The Asian variant was the most prevalent variant (81.8%) of HPV 16 in Taiwan, and was also associated with increased prevalence of histologically confirmed cervical intraepithelial neoplasia grade 3 or worse, showing an age-adjusted odds ratio (exact confidence limits) of 10.70 (1.62-451.05; P=0.0049) compared to the HPV 16 European variant. Similar significant associations with cervical intraepithelial neoplasia grade 3 or worse were also observed for distinct nucleotide substitutions, including T178A/G, A647G, A7730C/G, T7781C, G7842A, and C24T/G. These results demonstrate that non-European variants (non-E) of HPV 16, predominantly Asian variants, are associated with increased risk for severe cervical neoplasia, compared with European variants. Molecular mechanisms accounting for varied cervical neoplasia risk among different HPV 16 variants warrant further investigation.
頁(從 - 到)1567-1576
期刊Journal of Medical Virology
出版狀態已發佈 - 九月 2013


ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


Chang, Y. J., Chen, H. C., Pan, M. H., Lee, B. H., You, S. L., Lin, C. Y., Chou, Y. C., Hsieh, C. Y., Cheng, Y. J., Liaw, K. L., Hsing, A. W., Schiffman, M., & Chen, C. J. (2013). Intratypic variants of human papillomavirus type 16 and risk of cervical Neoplasia in Taiwan. Journal of Medical Virology, 85(9), 1567-1576.