Intraindividual Characterization of the Sleep Spindle Variability in Healthy Subjects

J. Gomez-Pilar, G. Northoff, F. Vaquerizo-Villar, J. Poza, G. C. Gutierrez-Tobal, R. Hornero

研究成果: 書貢獻/報告類型會議貢獻

1 引文 斯高帕斯(Scopus)

摘要

Spatial and frequency characterization of sleep spindles have been extensively addressed using M/EEG or fMRI recordings. However, its intraindividual variability across time has not been addressed. Here we propose to assess the intraindividual variability of sleep spindles in a time-resolved way by means of a trial-to-trial-variability (TTV) measure. For that purpose, the EEG of 26 healthy subjects were recorded overnight. After an exhaustive preprocessing pipeline to remove artifacts, spindles were automatically detected using a complex demodulation-based method. Then, the Wavelet Scalogram was estimated to validate it. Spindle TTV of each participant was also computed for all the conventional EEG frequency bands. Root mean square (RMS) of each TTV signal was calculated as a measure of the total variability of each spindle. Results showed significant differences in the variability between frequencies. Specifically, RMS in the beta-1 frequency band showed higher values as compared to all the other frequency bands (p<0.001). TTV curves showed a dichotomic trend, with lower frequencies showing an increase in the variability before the spindle onset, and higher frequencies showing such increase after the onset. The dependence of the spindle variability with the frequency could be explained by the influence of the multiple cortical generators involved.Clinical Relevance - Sleep spindles are similarly affected in different cognitive-related disorders, which supports the relevance of assessing abnormal sleep patterns as a possible cause for such cognitive deficits.

原文英語
主出版物標題42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
主出版物子標題Enabling Innovative Technologies for Global Healthcare, EMBC 2020
發行者Institute of Electrical and Electronics Engineers Inc.
頁面3473-3476
頁數4
ISBN(電子)9781728119908
ISBN(列印)9781728119908
DOIs
出版狀態已發佈 - 七月 2020
對外發佈
事件42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020 - Montreal, 加拿大
持續時間: 七月 20 2020七月 24 2020

出版系列

名字Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
2020-July
ISSN(列印)1557-170X

會議

會議42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020
國家/地區加拿大
城市Montreal
期間7/20/207/24/20

ASJC Scopus subject areas

  • 訊號處理
  • 生物醫學工程
  • 電腦視覺和模式識別
  • 健康資訊學

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