Intracellular oxidative cleavage of DNA in escherichia coli by the copper-1, 10-phenanthroline complex

Eleonore Lickl, Shiow Chyi Chao, Wen Chang Chang

研究成果: 雜誌貢獻文章同行評審

9 引文 斯高帕斯(Scopus)

摘要

Plasmid and chromosomal DNA of E. coli during exponential growth are cleaved after treatment with copper(II)-1, 10-phenanthroline complex (1: 2) without providing any exogenous reductant. About 1500 copper molecules per cell are present as estimated by atomic absorption analysis. Within the cell the endogenous reducing substances may have participated in the sequential oxidative reactions, which lead to the damage of DNA. A portion of the resultant DNA fragments originates from plasmid DNA as demonstrated by hybridization tests.
原文英語
頁(從 - 到)37-45
頁數9
期刊Free Radical Research
8
發行號1
DOIs
出版狀態已發佈 - 一月 1 1989
對外發佈

ASJC Scopus subject areas

  • 生物化學

指紋

深入研究「Intracellular oxidative cleavage of DNA in escherichia coli by the copper-1, 10-phenanthroline complex」主題。共同形成了獨特的指紋。

引用此