Interplay of epidermal growth factor receptor and signal transducer and activator of transcription 3 in prostate cancer: Beyond androgen receptor transactivation

Shian Ren Lin, Hsiu Lien Yeh, Yen Nien Liu

研究成果: 雜誌貢獻文章同行評審

摘要

Prostate cancer (PCa) is one of the most common cancers in the world and causes thou-sands of deaths every year. Conventional therapy for PCa includes surgery and androgen deprivation therapy (ADT). However, about 10–20% of all PCa cases relapse; there is also the further development of castration resistant adenocarcinoma (CRPC-Adeno) or neuroendocrine (NE) PCa (CRPC-NE). Due to their androgen-insensitive properties, both CRPC-Adeno and CRPC-NE have limited therapeutic options. Accordingly, this study reveals the inductive mechanisms of CRPC (for both CRPC-Adeno and CRPC-NE) and fulfils an urgent need for the treatment of PCa patients. Although previous studies have illustrated the emerging roles of epidermal growth factor receptors (EGFR), signal transducer, and activator of transcription 3 (STAT3) signaling in the development of CRPC, the regulatory mechanisms of this interaction between EGFR and STAT3 is still unclear. Our recent studies have shown that crosstalk between EGFR and STAT3 is critical for NE differentiation of PCa. In this review, we have collected recent findings with regard to the involvement of EGFR and STAT3 in malignancy progression and discussed their interactions during the development of therapeutic resistance for PCa.
原文英語
文章編號3452
期刊Cancers
13
發行號14
DOIs
出版狀態已發佈 - 7月 2 2021

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

指紋

深入研究「Interplay of epidermal growth factor receptor and signal transducer and activator of transcription 3 in prostate cancer: Beyond androgen receptor transactivation」主題。共同形成了獨特的指紋。

引用此