International differences in treatment and clinical outcomes for high grade glioma

Li Nien Chien, Quinn T. Ostrom, Haley Gittleman, Jia Wei Lin, Andrew E. Sloan, Gene H. Barnett, J. Bradley Elder, Christopher McPherson, Ronald Warnick, Yung Hsiao Chiang, Chieh Min Lin, Lisa R. Rogers, Hung Yi Chiou, Jill S. Barnholtz-Sloan

研究成果: 雜誌貢獻文章

4 引文 (Scopus)

摘要

Background: High grade gliomas are the most common type of malignant brain tumor, and despite their rarity, cause significant morbidity and mortality. This study aimed to compare the treatment patterns of high grade glioma to examine survival patterns in patients who receive specific treatments between cohorts in Ohio and Taiwan. Method: Patients aged 18 years and older at age of diagnosis with World Health Organization (WHO) grade III or IV astrocytoma from 2007-2012 were selected from the Ohio Brain Tumor Study and the Taiwan Cancer Registry. The treatment information was derived from medical chart reviews in Ohio and National Health Insurance Research Data in Taiwan. Treatment examined included surgical procedure (brain biopsy and/or resection), radiotherapy (radiation and/or radiosurgery), and alkylating chemotherapy. Kaplan-Meier and parametric survival models were used to examine the effect of treatment on survival, adjusted for age, sex, and comorbidities. Results: 294 patients in Ohio and 1,097 patients in Taiwan met the inclusion criteria. 70.3% patients in Ohio and 51.4% in Taiwan received surgical resection, followed by concurrent chemoradiation. Patients who received this treatment had the highest survival rate, with a 1-year survival rate of 72.8% in Ohio and 73.4% in Taiwan. Patients who did not receive surgical resection, followed by concurrent chemoradiation had an increased risk of death (hazard ratio of 5.03 [95% confidence interval (CI): 3.61-7.02] in Ohio and 1.49 [95% CI: 1.31-1.71] in Taiwan) after adjustment for age, sex, and comorbidities. Conclusion: Surgical resection followed by concurrent chemoradiation was associated with higher survival rate of patients with high grade glioma in both Ohio and Taiwan; however, one-third of patients in Ohio and half in Taiwan did not receive this treatment.
原文英語
文章編號e0129602
期刊PLoS One
10
發行號6
DOIs
出版狀態已發佈 - 六月 10 2015

指紋

Taiwan
Glioma
Brain
Tumors
resection
Health insurance
Chemotherapy
Biopsy
Radiotherapy
Hazards
Survival Rate
survival rate
Health
brain
Radiation
Brain Neoplasms
Therapeutics
neoplasms
Survival
Comorbidity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

引用此文

Chien, L. N., Ostrom, Q. T., Gittleman, H., Lin, J. W., Sloan, A. E., Barnett, G. H., ... Barnholtz-Sloan, J. S. (2015). International differences in treatment and clinical outcomes for high grade glioma. PLoS One, 10(6), [e0129602]. https://doi.org/10.1371/journal.pone.0129602

International differences in treatment and clinical outcomes for high grade glioma. / Chien, Li Nien; Ostrom, Quinn T.; Gittleman, Haley; Lin, Jia Wei; Sloan, Andrew E.; Barnett, Gene H.; Elder, J. Bradley; McPherson, Christopher; Warnick, Ronald; Chiang, Yung Hsiao; Lin, Chieh Min; Rogers, Lisa R.; Chiou, Hung Yi; Barnholtz-Sloan, Jill S.

於: PLoS One, 卷 10, 編號 6, e0129602, 10.06.2015.

研究成果: 雜誌貢獻文章

Chien, LN, Ostrom, QT, Gittleman, H, Lin, JW, Sloan, AE, Barnett, GH, Elder, JB, McPherson, C, Warnick, R, Chiang, YH, Lin, CM, Rogers, LR, Chiou, HY & Barnholtz-Sloan, JS 2015, 'International differences in treatment and clinical outcomes for high grade glioma', PLoS One, 卷 10, 編號 6, e0129602. https://doi.org/10.1371/journal.pone.0129602
Chien, Li Nien ; Ostrom, Quinn T. ; Gittleman, Haley ; Lin, Jia Wei ; Sloan, Andrew E. ; Barnett, Gene H. ; Elder, J. Bradley ; McPherson, Christopher ; Warnick, Ronald ; Chiang, Yung Hsiao ; Lin, Chieh Min ; Rogers, Lisa R. ; Chiou, Hung Yi ; Barnholtz-Sloan, Jill S. / International differences in treatment and clinical outcomes for high grade glioma. 於: PLoS One. 2015 ; 卷 10, 編號 6.
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abstract = "Background: High grade gliomas are the most common type of malignant brain tumor, and despite their rarity, cause significant morbidity and mortality. This study aimed to compare the treatment patterns of high grade glioma to examine survival patterns in patients who receive specific treatments between cohorts in Ohio and Taiwan. Method: Patients aged 18 years and older at age of diagnosis with World Health Organization (WHO) grade III or IV astrocytoma from 2007-2012 were selected from the Ohio Brain Tumor Study and the Taiwan Cancer Registry. The treatment information was derived from medical chart reviews in Ohio and National Health Insurance Research Data in Taiwan. Treatment examined included surgical procedure (brain biopsy and/or resection), radiotherapy (radiation and/or radiosurgery), and alkylating chemotherapy. Kaplan-Meier and parametric survival models were used to examine the effect of treatment on survival, adjusted for age, sex, and comorbidities. Results: 294 patients in Ohio and 1,097 patients in Taiwan met the inclusion criteria. 70.3{\%} patients in Ohio and 51.4{\%} in Taiwan received surgical resection, followed by concurrent chemoradiation. Patients who received this treatment had the highest survival rate, with a 1-year survival rate of 72.8{\%} in Ohio and 73.4{\%} in Taiwan. Patients who did not receive surgical resection, followed by concurrent chemoradiation had an increased risk of death (hazard ratio of 5.03 [95{\%} confidence interval (CI): 3.61-7.02] in Ohio and 1.49 [95{\%} CI: 1.31-1.71] in Taiwan) after adjustment for age, sex, and comorbidities. Conclusion: Surgical resection followed by concurrent chemoradiation was associated with higher survival rate of patients with high grade glioma in both Ohio and Taiwan; however, one-third of patients in Ohio and half in Taiwan did not receive this treatment.",
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AU - Elder, J. Bradley

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N2 - Background: High grade gliomas are the most common type of malignant brain tumor, and despite their rarity, cause significant morbidity and mortality. This study aimed to compare the treatment patterns of high grade glioma to examine survival patterns in patients who receive specific treatments between cohorts in Ohio and Taiwan. Method: Patients aged 18 years and older at age of diagnosis with World Health Organization (WHO) grade III or IV astrocytoma from 2007-2012 were selected from the Ohio Brain Tumor Study and the Taiwan Cancer Registry. The treatment information was derived from medical chart reviews in Ohio and National Health Insurance Research Data in Taiwan. Treatment examined included surgical procedure (brain biopsy and/or resection), radiotherapy (radiation and/or radiosurgery), and alkylating chemotherapy. Kaplan-Meier and parametric survival models were used to examine the effect of treatment on survival, adjusted for age, sex, and comorbidities. Results: 294 patients in Ohio and 1,097 patients in Taiwan met the inclusion criteria. 70.3% patients in Ohio and 51.4% in Taiwan received surgical resection, followed by concurrent chemoradiation. Patients who received this treatment had the highest survival rate, with a 1-year survival rate of 72.8% in Ohio and 73.4% in Taiwan. Patients who did not receive surgical resection, followed by concurrent chemoradiation had an increased risk of death (hazard ratio of 5.03 [95% confidence interval (CI): 3.61-7.02] in Ohio and 1.49 [95% CI: 1.31-1.71] in Taiwan) after adjustment for age, sex, and comorbidities. Conclusion: Surgical resection followed by concurrent chemoradiation was associated with higher survival rate of patients with high grade glioma in both Ohio and Taiwan; however, one-third of patients in Ohio and half in Taiwan did not receive this treatment.

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