Interleukin-28B genetic variants in identification of hepatitis C virus genotype 1 patients responding to 24 weeks peginterferon/ribavirin

Chung Feng Huang, Jee Fu Huang, Jeng Fu Yang, Ming Yen Hsieh, Zu Yau Lin, Shinn Cherng Chen, Liang Yen Wang, Suh Hang Hank Juo, Ku Chung Chen, Wan Long Chuang, Hsing Tao Kuo, Chia Yen Dai, Ming Lung Yu

研究成果: 雜誌貢獻文章

75 引文 斯高帕斯(Scopus)

摘要

Background & Aims: A substantial proportion of hepatitis C virus genotype 1 (HCV-1) patients achieved a sustained virological response (SVR, HCV RNA seronegative throughout 24 weeks of post-treatment follow-up) after 24 weeks peginterferon/ribavirin therapy. We explored the role of interleukin-28B genotype in identifying patients who responded to the regimen. Methods: Interleukin-28B rs8099917 genotype was determined in 226 HCV-1 patients with 24 weeks peginterferon/ribavirin. Results: Compared to patients with rs8099917 TG/GG genotype, those with TT genotype had significantly higher rapid virological response (RVR, HCV RNA seronegative at treatment week 4, 54.0% vs. 17.9%, p

原文英語
頁(從 - 到)34-40
頁數7
期刊Journal of Hepatology
56
發行號1
DOIs
出版狀態已發佈 - 一月 2012
對外發佈Yes

ASJC Scopus subject areas

  • Hepatology

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    Huang, C. F., Huang, J. F., Yang, J. F., Hsieh, M. Y., Lin, Z. Y., Chen, S. C., Wang, L. Y., Juo, S. H. H., Chen, K. C., Chuang, W. L., Kuo, H. T., Dai, C. Y., & Yu, M. L. (2012). Interleukin-28B genetic variants in identification of hepatitis C virus genotype 1 patients responding to 24 weeks peginterferon/ribavirin. Journal of Hepatology, 56(1), 34-40. https://doi.org/10.1016/j.jhep.2011.03.029