Interleukin-20 targets renal cells and is associated with chronic kidney disease

Chi Chen Wei, Hsing Hui Li, Yu Hsiang Hsu, Chung-Hsi Hsing, Junne Ming Sung, Ming Shi Chang

研究成果: 雜誌貢獻文章

21 引文 斯高帕斯(Scopus)

摘要

Interleukin (IL)-10 is an anti-inflammatory factor that suppresses renal fibrosis and improves renal function in CKD rats. IL-20 belongs to the IL-10 family; therefore, we sought to determine whether IL-20 is involved in CKD. CKD patients at stage five expressed significantly higher IL-20 in serum than controls. Immunohistochemical staining demonstrated that more IL-20 protein was expressed in the kidney tubular-epithelial cells, mesangial cells, and immune cells of CKD rats with a 5/6 nephrectomy. The lung, liver, and heart tissue of CKD rats also overexpressed IL-20. Thus, we treated two tubular epithelial cells, TKPTS and M-1 cells, with IL-20 to study its effects on CKD. IL-20 treatment induced apoptosis in these cells via caspase-3 activation. Incubating IL-20 with rat interstitial fibroblasts, NRK-49F cells, upregulated TGF-β1production, one key inducer for renal fibrogenesis. Therefore, IL-20 injured renal epithelial cells and induced fibroblasts to produce TGF-β1 that hastened the progression of CKD.

原文英語
頁(從 - 到)448-453
頁數6
期刊Biochemical and Biophysical Research Communications
374
發行號3
DOIs
出版狀態已發佈 - 九月 26 2008
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

指紋 深入研究「Interleukin-20 targets renal cells and is associated with chronic kidney disease」主題。共同形成了獨特的指紋。

  • 引用此